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个人信息

博士生导师、中国科学院院士
研究员

Email: hxlin@cemps.ac.cn
个人网页:

研究方向

作物遗传与功能基因组学研究

林鸿宣

个人简介

学历
1979.9－1983.7，华南农业大学作物遗传育种专业，学士
1983.9－1986.7，中国农业科学院研究生院作物遗传育种专业，硕士
1991.9－1994.7，中国农业科学院研究生院作物遗传育种专业，博士
工作经历
1986.8－1995.9， 中国水稻研究所，助理研究员、副研究员
1995.10-1996.9，日本国际农林水产业研究中心，博士后
1996.10-1997.7， 中国水稻研究所，副研究员
1997.8-2001.2， 日本国立农业生物资源研究所，博士后
2001.3起至今， 中国科学院上海植物生理生态研究所/分子植物卓越中心，研究员，博士生导师。2009年当选中国科学院院士。

研究工作

以模式作物水稻为研究材料，采用遗传学、分子生物学、植物生理学、基因组学、生物信息学等方法，开展控制作物重要复杂性状包括抗逆性（抗热、耐盐、抗旱）、产量等性状的基因（或QTL）克隆与分子遗传调控机理研究，阐明复杂性状的分子调控网络，为分子设计育种提供理论基础。

主要成果

本研究组主要对水稻抗逆性状（抗高温、抗旱、耐盐）、产量性状的分子遗传调控机理开展系统而深入的研究，成功分离克隆了多个“重量级”新基因（或QTLs）并阐明调控机制，如抗高温基因(TT1、TT2、TT3)、耐盐基因(SKC1、HAL3)、抗旱基因(DST、DCA1)、粒型基因(GW2、GL3.1、GSN1、GW6、GS3.1)、株型基因(PROG1)、生殖隔离基因(Hwi1和Hwi2)、协同调控粒型与抗非生物胁迫基因（GSA1）等，深入阐明了这些性状的分子遗传调控机理，为作物分子育种提供理论基础。

已发表学术论文六十余篇，包括多篇通讯作者论文发表在Science、Nature Genetics（4篇）、Nature Cell Biology、Nature Communications（2篇）、Nature Plants、Cell Research（2篇）、Genes & Development、Molecular Plant（5篇）、PLoS Genetics、Plant Cell（2篇）等国际著名杂志上。申请或授权专利18项。获国家自然科学奖二等奖，上海市自然科学奖一等奖；何梁何利科学与技术进步奖，第十二届谈家桢生命科学成就奖，CSPB杰出成就奖（植生学会），全国五一劳动奖章，全国优秀科技工作者；获全国优秀博士学位论文奖（2次），中科院优秀博士学位论文（5次）奖等。目前承担国家基金委基础科学中心、基金委重点、国家重点研发、中科院等科研项目。

    1. Zhang H, Zhou JF, Kan Y, Shan JX, Ye WW, Dong NQ, Guo T, Xiang YH, Yang YB, Li YC, Zhao HY, Yu HX, Lu ZQ, Guo SQ, Lei JJ, Liao B, Mu XR, Cao YJ, Yu JJ, Lin YS*, Lin HX*(2022). A genetic module at one locus in rice protects chloroplasts to enhance thermotolerance. Science, 376: 1293–1300.

    2. Kan Y, Mu XR, Zhang H, Gao J, Shan JX, Ye WW, Lin HX* (2022).TT2 controls rice thermotolerance through SCT1-dependent alteration of wax biosynthesis. Nature Plants, 8:53-67.

    3. Zhang YM, Yu HX, Ye WW, Shan JX, Dong NQ, Guo T, Kan Y, Xiang YH, Zhang H, Yang YB, Li YC, Zhao HY, Lu ZQ, Guo SQ, Lei JJ, Liao B, Mu XR, Cao YJ, Yu JJ, Lin HX* (2021). A rice QTL GS3.1 regulates grain size through metabolic-flux distribution between flavonoid and lignin metabolons without affecting stress tolerance. Communications Biology, 4: 1171.

    4. Dong NQ, Sun YW, Guo T, Shi CL, Zhang YM, Kan Y, Xiang YH, Zhang H, Yang YB, Li YC, Zhao HY, Yu HX, Lu ZQ, Wang Y, Ye WW*, Shan JX*, Lin HX* (2020). UDP-glucosyltransferase regulates grain size and abiotic stress tolerance associated with metabolic flux redirection in rice. Nature Communications, 11(1): 2629.

    5. Guo T, Lu ZQ, Shan JX, Ye WW, Dong NQ, Lin HX* (2020). ERECTA1 Acts Upstream of the OsMKKK10-OsMKK4-OsMPK6 Cascade to Control Spikelet Number by Regulating Cytokinin Metabolism in Rice. The Plant Cell, 32(9): 2763-2779.

    6. Guo T, Chen HC, Lu ZQ, Diao M, Chen K, Dong NQ, Shan JX, Ye WW, Huang SJ, Lin HX* (2020). A SAC Phosphoinositide Phosphatase Controls Rice Development via Hydrolyzing PI4P and PI(4,5)P2. Plant Physiology, 182(3): 1346-1358.

    7. Shi CL, Dong NQ, Guo T, Ye WW, Shan JX, Lin HX* (2020). A quantitative trait locus GW6 controls rice grain size and yield through the gibberellin pathway. The Plant Journal, 103(3): 1174-1188.

    8. Chen K, Guo T, Li XM, Zhang YM, Yang YB, Ye WW, Dong NQ, Shi CL, Kan Y, Xiang YH, Zhang H, Li YC, Gao JP, Huang X, Zhao Q, Han B, Shan JX, Lin HX*. Translational Regulation of Plant Response to High Temperatureby a Dual Function tRNAHis Guanylyltransferase in Rice. Molecular Plant, 2019, doi: https://doi.org/10.1016/j.molp.2019.04.012.

    9. Guo T, Chen K, Dong NQ, Shi CL, Ye WW, Gao JP, Shan JX*, Lin HX*. GRAIN SIZE AND NUMBER1 negatively regulates the OsMKKK10-OsMKK4-OsMPK6 cascade to coordinate the trade-off between grain number per panicle and grain size in rice. Plant Cell, 2018, 30: 871-888.

    10. Li XM, Lin HX*. Molecular signature of chilling adaptation in rice. National Science Review, 2016, 3: 276-277.

    11. Su L, Shan JX, Gao JP, Lin HX*. OsHAL3, a blue light-responsive protein, interacts with the floral regulator Hd1 to activate flowering in rice. Molecular Plant, 2016, 9(2): 233-244.

    12. Wu Y, Wang Y, Mi XF, Shan JX, Li XM, Xu JL*, Lin HX*. The QTL GNP1 Encodes GA20ox1, Which Increases Grain Number and Yield by Increasing Cytokinin Activity in Rice Panicle Meristems. PLoS Genetics, 2016, 12(10): e1006386.

    13. Cui LG, Shan JX, Shi M, Gao JP*, Lin HX*. DCA1 acts as a transcriptional co-activator of DST and contributes to drought and salt tolerance in rice. PLoS Genetics, 2015, 11(10): e1005617. doi:10.1371/journal.pgen.1005617.

    14. Li XM, Chao DY, Wu Y, Huang X, Chen K, Cui LG, Su L, Ye WW, Chen H, Chen HC, Dong NQ, Guo T, Shi M, Feng Q, Zhang P, Han B, Shan JX*, Gao JP*, Lin HX*. Natural alleles of a proteasome α2 subunit gene contribute to thermotolerance and adaptation of African rice. Nature Genetics, 2015, 42(7): 827-833.

    15. Chen C, Chen H, Lin YS, Shen JB, Shan JX, Qi P, Shi M, Zhu MZ, Huang XH, Feng Q, Han B, Jiang L, Gao JP*, Lin HX*. A two-locus interaction causes interspecific hybrid weakness in rice. Nature Communications, 2014, 5: 3357 doi: 10.1038/ncomms4357.

    16. Chen C, Chen H, Shan JX, Zhu MZ, Shi M, Gao JP*, Lin HX*. Genetic and Physiological Analysis of a Novel Type of Interspecific Hybrid Weakness in Rice. Molecular Plant, 2013, 6(3): 716-728.

    17. Qi P, Lin YS, Song XJ, Shen JB, Huang W, Shan JX, Zhu MZ, Jiang LW, Gao JP*, Lin HX*. The Novel Quantitative Trait Locus GL3.1 Controls Rice Grain Size and Yield by Regulating Cyclin-T1;3. Cell Research, 2012, 22(12): 1666-1680.

    18. Lv MZ, Chao DY, Shan JX, Zhu MZ, Shi M, Gao JP, Lin HX*. Rice Carotenoid β-ring Hydroxylase CYP97A4 is Involved in Lutein Biosynthesis. Plant and Cell Physiology, 2012, 53(6): 987-1002.

    19. Ying JZ, Shan JX, Gao JP, Zhu MZ, Shi M, Lin HX*. Identification of Quantitative Trait Loci for Lipid Metabolism in Rice Seeds. Molecular Plant, 2012, 5(4): 865-875.

    20. Ying JZ, Gao JP, Shan JX, Zhu MZ, Shi M, Lin HX*. Dissecting the Genetic Basis of Extremely Large Grain Shape in Rice Cultivar ‘JZ1560’. Journal of Genetics and Genomics, 2012, 39: 325-333.

    21. Chao DY*, Lin HX*. The tricks plants use to reach appropriate light. SCIENCE CHINA Life Sciences, 2010, 53 (8): 916-926.

    22. Hao W, Lin HX*. Toward understanding genetic mechanisms of complex traits in rice. J. Genet. Genomics, 2010, 37: 1-14.

    23. Lan WZ, Wang W, Wang SM, Li LG, Buchanan BB, Lin HX, Gao JP, Luan S*. A rice high-affinity potassium transporter (HKT) conceals a calcium-permeable cation channel. Proceedings of the National Academy of Sciences USA, 2010, 107(15): 7089-7094.

    24. Sun SY, Chao DY, Li XM, Shi M, Gao JP, Zhu MZ, Yang HQ, Luan S, Lin HX*. OsHAL3 mediates a new pathway in light-regulated growth of rice. Nature Cell Biology , 2009, 11 (7) : 845-851.

    25. Huang XY, Chao DY, Gao JP, Zhu MZ, Shi M, Lin HX*. A previously unknown zinc finger protein, DST, regulates drought and salt tolerance in rice via stomatal aperture control. Genes & Development, 2009, 23 (15): 1805–1817.

    26. Shan Jun-Xiang, Zhu Mei-Zhen, Shi Min, Gao Ji-Ping, Lin HX*. Fine mapping and candidate gene analysis of spd6, responsible for small panicle and dwarfness in wild rice (Oryza rufipogon Griff.). Theor Appl Genet, 2009, 119: 827-836.

    27. Hao Wei, Zhu Mei-Zhen, Gao Ji-Ping, Sun Shi-Yong, Lin HX*. Identification of quantitative trait loci for rice quality in a population of chromosome segment substitution lines. J Integr Plant Biol, 2009, 51: 500-512.

    28. Jin J, Huang W, Gao JP, Yang J, Shi M, Zhu MZ, Luo D, Lin HX*. Genetic control of rice plant architecture under domestication. Nature Genetics, 2008, 40(11): 1365-1369.

    29. Ge LF, Chao DY, Shi M, Zhu MZ, Gao JP, Lin HX*. Overexpression of the trehalose-6-phosphate phosphatase gene OsTPP1 confers stress tolerance in rice and results in the activation of stress responsive genes. Planta, 2008, 228: 191-201.

    30. Luo JJ, Hao W, Jin J, Gao JP, Lin HX*. Fine mapping of Spr3, a locus for spreading panicle from African cultivated rice (Oryza glaberrima Steud.). Molecular Plant, 2008, 1(5): 830–838.

    31. Gao JP, Chao DY, Lin HX*. Toward Understanding Molecular Mechanisms of Abiotic Stress Responses in Rice. Rice, 2008, 1: 36–51

    32. Wang ET, Wang JJ, Zhu XD, Wei H, Wang L, Li Q, Zhang LX, He W, Lu BR, Lin HX, Ma H, Zhang GQ, He ZH. Control of rice grain-filling and yield by a gene with a potential signature of domestication. Nature Genetics, 2008, 40(11): 1370-1374

    33. Xiang H, Li MW, Yang F, Guo QH, Zhan S, Lin HX, Miao XX, Huang YP. Fine mapping of Ekp-1, a locus associated with silkworm (Bombyx mori) proleg development. Heredity, 2008, 100: 533–540

    34. Song XJ, Huang W, Shi M, Zhu MZ, Lin HX*. A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase. Nature Genetics, 2007, 39 (5): 623-630

    35. Gao JP, Chao DY, Lin HX*. Understanding abiotic stress tolerance mechanisms: recent studies on stress response in rice. Journal of Integrative Plant Biology, 2007, 49 (6): 742?750

    36. Platten JD, Cotsaftis O, Berthomieu P, Bohnert H, Davenport RJ, Fairbairn DJ, Horie T, Leigh RA, Lin HX, Luan S, Maser P, Pantoja O, Rodriguez-Navarro A, Schachtman DP, Schroeder JI, Sentenac H, Uozumi N, Very AA, Zhu JK, Dennis ES, Tester M. Nomenclature for HKT transporters, key determinants of plant salinity tolerance. Trends in Plant Science, 2006, 11: 372-374

    37. Ren ZH, Gao JP, Li LG, Cai XL, Huang W, Chao DY, Zhu MZ, Wang ZY, Luan S*, Lin HX*. A rice quantitative trait locus for salt tolerance encodes a sodium transporter. Nature Genetics, 2005, 37 (10): 1141-1146

    38. Chao DY, Luo YH, Shi M, Luo D, Lin HX*. Salt-responsive genes in rice revealed by cDNA microarray analysis. Cell Research, 2005, 15(10): 796-810