首页　　 人才队伍
个人信息

博士生导师
研究员

2022年获得“科学探索奖”
2015年获得“国家杰出青年基金”


Email: jwwang@cemps.ac.cn
个人网页: http://wanglab.sippe.ac.cn/

研究方向

植物时序性发育和生命周期

王佳伟

个人简介

1995-1999，上海交通大学生命科学与技术学院，学士
1999-2005，中国科学院上海生命科学研究院植物生理生态研究所，博士
2005-2011，Max Planck Institute for Developmental Biology，博士后
2011-，中国科学院上海生命科学研究院植物生理生态研究所，研究员

研究工作

年龄是多细胞生命体的基本特征之一。随着年龄的增长，生命体的生理与性状随之改变。常见的变化包括形态上的差异、再生能力的下降、代谢产物的异同以及对环境感应性的改变。与动物相比，植物的年龄策略又呈现出多样性。按照生活周期可分为：一年生（annual）、二年生（biennial）及多年生（perennial）。实验室以一年生草本植物--拟南芥（Arabidopsis thaliana）和十字花科多年生草本植物为模式，利用遗传学，反向遗传学、单细胞测序和细胞谱系追踪技术，回答如下一些科学问题：
1）植物如何从一个单细胞合子通过细胞分裂和分化发育成为一个多细胞的个体；
2）年龄不可逆的分子机理；
3）年龄如何调控植物再生能力和干细胞基因组的稳定性；
4）植物生活习性自然变异的遗传学基础；
5）多年生植物生活习性及其干细胞长久维持的分子机理。

主要成果

 


    1. Zhai D#, Zhang LY#, Li LZ#, Xu ZG#, Liu XL, Shang GD, Zhao B, Gao J, Wang FX, and Wang JW*. (2024). Reciprocal conversion between annual and polycarpic perennial flowering behavior in the Brassicaceae. Cell. 187(13): 3319-3337.

    2. Zhou CM#, Li JX#, Zhang TQ, Xu ZG, Ma ML, Zhang P*, and Wang JW*. (2024).The structure of B-ARR reveals the molecular basis of transcriptional activation by cytokinin. Proc Natl Acad Sci USA. 121(3): e2319335121.

    3. Zhao B and Wang JW*. (2024). Perenniality: from model plants to applications in agriculture. Mol Plant. 17(1): 141-157.

    4. Wang L, Wan MC, Liao RY, Xu J, Xu ZG, Xue HC, Mai YX, and Wang JW*. (2023).The maturation and aging trajectory of Marchantia polymorpha at single-cell resolution. Dev Cell. 58(15): 1429-1444.

    5. Liao RY and Wang JW*. (2023). Analysis of meristems and plant regeneration at single-cell resolution. Curr Opin Plant Biol. 74: 102378.

    6. Li LZ, Xu ZG, Chang TG, Wang L, Kang H, Zhai D, Zhang LY, Zhang P, Liu H, Zhu XG, and Wang JW*. (2023). Common evolutionary trajectory of short life-cycle in Brassicaceae ruderal weeds. Nat Commun. 14: 290.

    7. Tang HB, Wang J, Wang L, Shang GD, Xu ZG, Mai YX, Liu YT, Zhang TQ, and Wang JW*. (2023). Anisotropic cell growth at the leaf base promotes age-related changes in leaf shape in Arabidopsis thaliana. Plant Cell. 35(5): 1386-1407.

    8. Wang FX, Shang GD, and Wang JW*. (2022). Towards a hierarchical gene regulatory network underlying somatic embryogenesis. Trends Plant Sci. 27(12): 1209-1217.

    9. Gao J#, Zhang K#, Cheng YJ#, Shang GD, Wang FX, Wu LY, Xu ZG, Mai YX, Zhao XY, Zhai D, Lian H, and Wang JW*. (2022). A robust mechanism for reset of juvenility during each generation in Arabidopsis. Nat Plants. 8(3): 257-268.

    10. Wu LY#, Shang GD#, Wang FX, Gao J, Wan MC, Xu ZG, and Wang JW*. (2022). Dynamic chromatin state profiling reveals regulatory roles of auxin and cytokinin in shoot regeneration. Dev Cell. 57(4): 526-542.

    11. Huang K#, Wu XX#, Fang CL#, Xu ZG#, Zhang HW, Gao J, Zhou CM, You LL, Gu ZX, Mu WH, Feng Y*, Wang JW*, and Zhang Y*. (2021). Pol IV and RDR2: a two-RNA-polymerase machine that produces double-stranded RNA. Science. 374(6575): 1579-1586.

    12. Cheng YJ, Shang GD, Xu ZG, Yu S, Wu LY, Zhai D, Tian SL, Gao J, Wang L, and Wang JW*. (2021). Cell division in the shoot apical meristem is a trigger for miR156 decline and vegetative phase transition in Arabidopsis. Proc Natl Acad Sci USA.118(46): e2115667118.

    13. Zhang TQ, Chen Y, Liu Y, and Wang JW*. (2021). Single-cell transcriptome atlas and chromatin accessibility landscape reveal differentiation trajectories in the rice root. Nat Commun. 12: 2053.

    14. Zhang TQ, Chen Y, and Wang JW*. (2021). A single-cell analysis of the Arabidopsis vegetative shoot apex. Dev Cell.56(7): 1056-1074.

    15. Lian H, Wang L, Ma N, Zhou CM, Han L, Zhang TQ, and Wang JW*. (2021). Redundant and specific roles of individual MIR172 genes in plant development. PLoS Biol. 19(2): e3001044.

    16. Wang FX#, Shang GD#, Wu LY, Xu ZG, Zhao XY, and Wang JW*. (2020). Chromatin accessibility dynamics and a hierarchical structure of transcriptional regulatory network for plant somatic embryogenesis. Dev Cell. 54(6): 742-757.

    17. Ye BB, Shang GD, Pan Y, Xu ZG, Zhou CM, Mao YB, Bao N, Sun L, Xu T, and Wang JW*. (2020).AP2/ERF transcription factors integrate age and wound signals for root regeneration. Plant Cell. 32(1): 226-241.

    18. Wang L#, Zhou CM#, Mai YX, Li LZ, Gao J, Shang GD, Lian H, Han L, Zhang TQ, Tang HB, Ren H, Wang FX, Wu LY, Liu XL, Wang CS, Chen EW, Zhang XN, Liu C, and Wang JW*. (2019). A spatiotemporally regulated transcriptional complex underlies heteroblastic development of leaf hairs in Arabidopsis thaliana. EMBO J. 38(8): 100063.

    19. Zhang TQ#, Xu ZG#, Shang GD, and Wang JW*. (2019). A single-cell RNA sequencing profiles the developmental landscape of Arabidopsis root. Mol Plant. 12(5): 648-660.

    20. Zhang TQ, Lian H, Zhou CM, Xu L, Jiao YL, and Wang JW*. (2017). A two-step model for de novo activation of WUSCHEL during plant shoot regeneration. Plant Cell. 29(5): 1073-1087.

    21. Yu S, Lian H, and Wang JW*. (2015). Plant developmental transitions: the role of microRNAs and sugars. Curr Opin Plant Biol. 27: 1-7.

    22. Zhang TQ, Lian H, Tang H, Dolezal K, Zhou CM, Yu S, Chen JH, Chen Q, Liu H, Ljung K, and Wang JW*. (2015). An intrinsic microRNA timer regulates progressive decline in shoot regenerative capacity in plants. Plant Cell. 27(2): 349-360.

    23. Rubio-Somoza I, Zhou CM, Confraria A, Martinho C, Born P, Baena-Gonzalez E, Wang JW*, and Weigel D*. (2014). Temporal control of leaf complexity by miRNA-regulated licensing of protein complexes. Curr Biol. 24(22): 2714-2719.

    24. Zhou CM, Zhang TQ, Wang X, Yu S, Lian H, Tang H, Feng ZY, Zozomova-Lihova J, and Wang JW*. (2013). Molecular basis of age-dependent vernalization in Cardamine flexuosa. Science. 340(6136): 1097-1100.

    25. Yu S, Cao L, Zhou CM, Zhang TQ, Lian H, Sun Y, Wu JQ, Huang JR, Wang GD, and Wang JW*. (2013). Sugar is an endogenous cue for juvenile-to-adult phase transition in plants. eLife. 2: e00269.

    26. Yu S#, Galvao V#, Zhang YC, Horrer D, Zhang TQ, Hao YH, Feng YQ, Wang S, Schmid M, and Wang JW*. (2012). Gibberellin regulates Arabidopsis floral transition through miR156-targeted SQUAMOSA PROMOTER BINDING-LIKE transcription factors. Plant Cell. 24(8): 3320-3332.

    27. Gou JY, Felipes FF, Liu CJ, Weigel D, and Wang JW*. (2011). Negative Regulation of anthocyanin biosynthesis in Arabidopsis by a miR156-targeted SPL transcription factor. Plant Cell. 23(4): 1512-1522.

    28. Wang JW*#, Park MY#, Wang LJ, Chen XY, Weigel D, and Poethig S*. (2011). MiRNA control of vegetative phase change in trees. PLOS Genet. 7: e1002012