首页　　 人才队伍
个人信息

博士生导师
研究员

Email: cgduan@cemps.ac.cn
个人网页:

研究方向

表观遗传与植物-病原互作

段成国

个人简介

2004年9月- 2008年7月，中科院微生物研究所，博士
2008年7月- 2011年10月，中国科学院微生物研究所，助理研究员
2011年11月- 2016年10月，美国普渡大学，博士后
2016年11月-2020年4月，中科院上海生命科学研究院/上海植物逆境生物学研究中心，研究员，博士生导师
2020年5月至今：中科院分子植物科学卓越创新中心/上海植物逆境生物学研究中心，研究员，博士生导师

研究工作

表观遗传修饰作为遗传信息的重要载体，在生命体发育时序性、可塑性及与环境因子的互作中发挥着关键作用。相比其它物种，植物表观遗传通路既有保守性又有特异性。免疫基因受环境因子诱导，富含各种表观修饰，是研究表观遗传调控的理想靶标。本研究组以模式植物拟南芥及农作物水稻，棉花，番茄等为研究材料，以遗传学、分子生物学、生物化学及生物信息学为主要研究手段，探索植物特有的表观遗传机制，并解析表观遗传机制在植物免疫力形成以及植物-病原互作中的调控作用。主要研究方向有：
1. 植物表观遗传信息（DNA甲基化、组蛋白修饰）的催化、识别与作用机制；
2. 非编码RNA及RNA修饰在植物-病原微生物互作中的作用；
3. 植物病原真菌致病机制及抗病策略开发。

主要成果

    1. Xie SS#, Zhang YZ#, Peng L, Yu DT, Zhu G, Zhao QZ, Wang CH, Xie Q, Duan CG*. JMJ28 guides sequence-specific targeting of ATX1/2-containing COMPASS-like complex in Arabidopsis. Cell Rep. 2023, 42 (3): 112163.

    2. Zhang J#, Yuan J#, Lin J#, Chen L, You LY, Chen S, Peng L, Wang CH, Du J*, Duan CG*. Molecular basis of locus-specific H3K9 methylation catalyzed by SUVH6 in plants. Proc Natl Acad Sci U S A. 2023, 120 (1): e2208525120.

    3. Liu T, Xu LG, Duan CG*. The trans-kingdom communication of noncoding RNAs in plant-environment interactions. Plant Genome, 2022: e20289.

    4. Chang YN#, Wang ZJ#, Ren Z, Wang CH, Wang P, Zhu JK, Li X*, Duan CG*. NUCLEAR PORE ANCHOR and EARLY IN SHORT DAYS 4 negatively regulate abscisic acid signaling by inhibiting Snf1-related protein kinase2 activity and stability in Arabidopsis. J Integr Plant Biol. 2022, 64 (11): 2060-2074.

    5. Zhu C#, Liu JH#, Zhao JH, Liu T, Chen YY, Wang CH, Zhang ZH, Guo HS, Duan CG*. A fungal effector suppresses the nuclear export of AGO1-miRNA complex to promote infection in plants. Proc Natl Acad Sci U S A. 2022, 119(12): e2114583119.

    6. You LY#, Lin J#, Xu HW#, Chen CX, Chen JY, Zhang J, Zhang J, Li YX, Ye C, Zhang H, Jiang J, Zhu JK, Li QQ*, Duan CG*. Intragenic heterochromatin-mediated alternative polyadenylation modulates miRNA and pollen development in rice. New Phytol. 2021, 232 (2): 835-852.

    7. Zhang YZ#, Lin J#, Ren Z#, Chen CX#, Miki D#, Xie SS, Zhang J, Chang YN, Jiang J, Yan J, Li QQ*, Zhu JK*, Duan CG*. Genome-wide distribution and functions of the AAE complex in epigenetic regulation in Arabidopsis. J Integr Plant Biol. 2021, 63 (4): 707-722.

    8. Zhang YZ#, Yuan JL#, Zhang L#, Chen CX, Wang Y, Zhang G, Peng L, Xie SS, Jiang J, Zhu JK*, Duan J*, Duan CG*. Coupling of H3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2 complex in Arabidopsis. Nat Commun. 2020 11 (1): 6212.

    9. Zhang J, Zhang YZ, Jiang J, Duan CG*. The crosstalk between epigenetic mechanisms and alternative RNA processing regulation. Front Genet. 2020, 11: 998.

    10. Chang YN, Zhu C, Jiang J, Zhang H, Zhu JK, Duan CG*. Epigenetic regulation in plant abiotic stress responses. J Integr Plant Biol. 2020, 62 (5): 563-580.

    11. Cui C#, Wang JJ#, Zhao JH#, Fang YY, He XF, Guo HS, Duan CG*. A Brassica miRNA Regulates Plant Growth and Immunity through Distinct Modes of Action. Mol Plant. 2020, 13 (2): 231-245.

    12. Zhu C, Liu T, Chang YN, Duan CG*. Small RNA Functions as a Trafficking Effector in Plant Immunity. Int J Mol Sci. 2019, 20 (11): 2816.

    13. Zhu G, Chang Y, Xu X, Tang K, Chen C, Lei M, Zhu JK, Duan CG*. EXPORTIN 1A prevents transgene silencing in Arabidopsis by modulating nucleo-cytoplasmic partitioning of HDA6. J Integr Plant Biol. 2019, 61 (12): 1243-1254.

    14. Duan CG*, Zhu JK*, Cao X*. Retrospective and perspective of plant epigenetics in China. J Genet Genomics. 2018, 45 (11): 621-638.

    15. Duan CG#*, Wang X#, Zhang L, Xiong X, Zhang Z, Tang K, Pan L, Hsu CC, Xu H, Tao WA, Zhang H, Zhu JK*. A protein complex regulates RNA processing of intronic heterochromatin-containing genes in Arabidopsis. Proc Natl Acad Sci U S A. 2017,114 (35): e7377-E7384.

    16. Duan CG*, Zhu JK. Dissecting the Subnuclear Localization Patterns of Argonaute Proteins and Other Components of the RNA-Directed DNA Methylation Pathway in Plants. Methods Mol Biol. 2017, 1640: 129-135.

    17. Duan CG#, Wang X#, Xie S, Pan L, Miki D, Tang K, Hsu CC, Lei M, Zhong Y, Hou YJ, Wang Z, Zhang Z, Mangrauthia SK, Xu H, Zhang H, Dilkes B, Tao WA, Zhu JK. A pair of transposon-derived proteins function in a histone acetyltransferase complex for active DNA demethylation. Cell Res. 2017, 27 (2): 226-240.

    18. Fang YY, Zhao JH, Liu SW, Wang S, Duan CG*, Guo HS*. CMV2b-AGO Interaction Is Required for the Suppression of RDR-Dependent Antiviral Silencing in Arabidopsis. Front Microbiol. 2016, 24 (7): 1329.

    19. Duan CG#, Wang X#, Tang K, Zhang H, Mangrauthia SK, Lei M, Hsu CC, Hou YJ, Wang C, Li Y, Tao WA, Zhu JK*. MET18 Connects the Cytosolic Iron-Sulfur Cluster Assembly Pathway to Active DNA Demethylation in Arabidopsis. PLoS Genet. 2015, 11 (10): e1005559.

    20. Li Y#, Duan CG#, Zhu X, Qian W, Zhu JK*. A DNA ligase required for active DNA demethylation and genomic imprinting in Arabidopsis. Cell Res. 2015, 25 (6): 757-60.

    21. Duan CG#, Zhang H#, Tang K#, Zhu X, Qian W, Hou YJ, Wang B, Lang Z, Zhao Y, Wang X, Wang P, Zhou J, Liang G, Liu N, Wang C, Zhu JK*. Specific but interdependent functions for Arabidopsis AGO4 and AGO6 in RNA-directed DNA methylation. EMBO J. 2015, 34 (5): 581-92.

    22. Wang X#, Duan CG#, Tang K, Wang B, Zhang H, Lei M, Lu K, Mangrauthia SK, Wang P, Zhu G, Zhao Y, Zhu JK. RNA-binding protein regulates plant DNA methylation by controlling mRNA processing at the intronic heterochromatin-containing gene BM1. Proc Natl Acad Sci U S A. 2013, 110 (38): 15467-72.

    23. Feng L#, Duan CG#, Guo HS*. Inhibition of in vivo slicer activity of Argonaute protein 1 by the viral 2b protein independent of its dsRNA-binding function. Mol Plant Pathol. 2013, 14 (6): 617-22.

    24. Duan CG, Wang CH, Guo HS*. Application of RNA silencing to plant disease resistance. Silence. 2012 May 31;3(1):5.

    25. Duan CG#, Fang YY#, Zhou BJ, Zhao JH, Hou WN, Zhu H, Ding SW, Guo HS*. Suppression of Arabidopsis ARGONAUTE1-mediated slicing, transgene-induced RNA silencing, and DNA methylation by distinct domains of the Cucumber mosaic virus 2b protein. Plant Cell. 2012,24(1):259-74.

    26. Hou WN#, Duan CG#, Fang RX, Zhou XY, Guo HS*. Satellite RNA reduces expression of the 2b suppressor protein resulting in the attenuation of symptoms caused by Cucumber mosaic virus infection. Mol Plant Pathol. 2011, 12 (6): 595-605.

    27. Duan CG, Wang CH, Fang RX, Guo HS*. Artificial MicroRNAs highly accessible to targets confer efficient virus resistance in plants. J Virol. 2008, 82 (22): 11084-11095.

    28. Du QS#, Duan CG#, Zhang ZH#, Fang YY, Fang RX, Xie Q, Guo HS*. DCL4 targets Cucumber mosaic virus satellite RNA at novel secondary structures. J Virol. 2007, 81 (17): 9142-9151.