个人信息

博士生导师
研究员

Email: wbyang@cemps.ac.cn
个人网页:

研究方向

植物干细胞维持和分化

杨卫兵

个人简介

2003.9-2007.6 南京大学生命科学学院,学士
2007.9-2013.7 中国科学院上海生命科学研究院植物生理生态研究所,博士
2014.1-2020.8 The Sainsbury Laboratory, University of Cambridge,博士后
2020.9-至今,中国科学院分子植物科学卓越创新中心,研究员

研究工作

植物干细胞是一类具有自我更新和增殖能力的细胞群,分布于各类分生组织中,如茎尖和根端分生组织、维管束形成层、叶表皮细胞等。干细胞呈现高度的动态特征,能通过不断的分裂维持分生组织的大小,并分化形成各种细胞类型。干细胞的维持及分化是植物生长发育和形态建成(morphogenesis)的基础。尤为重要的是,在禾本科植物中,干细胞的活性与穗原基的发育紧密相关,进而直接影响作物产量。植物干细胞的发育不仅被内在的物理(机械)和化学(激素)信号调控,还受到各类环境因素的影响。我们实验室主要以拟南芥和水稻为研究对象,探索如下的科学问题:
1) 植物干细胞维持和分化的分子机理;
2) 环境信号对干细胞活力的影响;
3) 植物干细胞动态过程中细胞壁的重塑。

主要成果

    1. Yang W, Cortijo S, Korsbo N, Roszak P, Schiessl K, Gurzadyan A, Wightman R, Jonsson H, Meyerowitz E. (2021). Molecular mechanism of cytokinin-activated cell division in Arabidopsis. Science 371: 1350-1355.

    2. Gao M, He Y, Yin X, Zhong X, Yan B, Wu Y, Chen J, Li X, Zhai K, Huang Y, Gong X, Chang H, Xie S, Liu J, Yue J, Xu J, Zhang G, Deng Y, Wang E, Tharreau D, Wang GL, Yang W*, He Z*. (2021). Ca2+ sensor-mediated ROS scavenging suppresses rice immunity and is exploited by a fungal effector. Cell 184: 5391-5404. (*co-corresponding author)

    3. Yang W, Schuster C, Prunet N, Dong Q, Landrein B, Wightman R, Meyerowitz EM. (2020). Visualization of protein coding, long noncoding, and nuclear RNAs by fluorescence in situ hybridization in sections of shoot apical meristems and developing flowers. Plant Physiology 182: 147-158.

    4. Yang W, Wightman R, Meyerowitz EM. (2017). Cell cycle control by nuclear sequestration of CDC20 and CDH1 mRNA in plant stem cells. Molecular Cell 68: 1108-1119.

    5. Yang W, Schuster C, Beahan CT, Charoensawan V, Peaucelle A, Bacic A, Doblin MS, Wightman R, Meyerowitz EM. (2016). Regulation of meristem morphogenesis by cell wall synthases in Arabidopsis. Current Biology 26: 1404-1415.

    6. Yang W, Gao M, Yin X, Liu J, Xu Y, Zeng L, Li Q, Zhang S, Wang J, Zhang X, He Z. (2013). Control of rice embryo development, shoot apical meristem maintenance, and grain yield by a novel cytochrome P450. Molecular Plant 6: 1945-1960.

    7. Yang W#, Ren S#, Zhang X#, Gao M, Ye S, Qi Y, Zheng Y, Wang J, Zeng L, Li Q, Huang S, He Z. (2011). BENT UPPERMOST INTERNODE1 encodes the class II formin FH5 crucial for actin organization and rice development. Plant Cell 23: 661-680. (#co-first author)

    8. Gao M#, Yin X#, Yang W#, Lam SM, Tong X, Liu J, Wang X, Li Q, Shui G, He Z. (2017). GDSL lipases modulate immunity through lipid homeostasis in rice. PLoS Pathogens 13: e1006724. (#co-first author)

    9. Prunet N, Yang W, Das P, Meyerowitz EM, Jack TP. (2017). SUPERMAN prevents class B gene expression and promotes stem cell termination in the fourth whorl of Arabidopsis thaliana flowers. PNAS 114: 7166-7171.

    10. You Q, Zhai K, Yang D, Yang W, Wu J, Liu J, Pan W, Wang J, Zhu X, Jian Y, Liu J, Zhang Y, Deng Y, Li Q, Lou Y, Xie Q, He Z. (2016). An E3 ubiquitin ligase-BAG protein module controls plant innate immunity and broad-spectrum disease resistance. Cell Host Microbe. 20: 758-769.

    11. Yu N, Luo D, Zhang X, Liu J, Wang W, Jin Y, Dong W, Liu J, Liu H, Yang W, Zeng L, Li Q, He Z, Oldroyd G, Wang E. (2014). A DELLA protein complex controls the arbuscular mycorrhizal symbiosis in plants. Cell Research 24:130-133.

    12. Zhang Y, Zhang B, Yan D, Dong W, Yang W, Li Q, Zeng L, Wang J, Wang L, Hicks LM, He Z. (2011). Two Arabidopsis cytochrome P450 monooxygenases, CYP714A1 and CYP714A2, function redundantly in plant development through gibberellin deactivation. Plant Journal 67: 342-353.