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个人信息

博士生导师
研究员

 


Email: yangzhao@psc.ac.cn
个人网页: https://www.psc.ac.cn/research_vpersonal.asp?id=27

研究方向

渗透胁迫信号传导

赵杨

个人简介

教育经历：
2000年09月-2004年06月，中国农业大学，本科，生物科学
2004年09月-2009年06月，中国农业大学与北京生命科学研究所，博士，植物学

工作经历：
2009年6月-2011年6月，北京生命科学研究所，博士后
2011年6月-2012年1月，中国农业大学，博士后
2012年2月-2016年12月，美国，普渡大学，博士后
2016年12月-至今，中国科学院分子植物科学卓越创新中心，上海植物逆境生物学研究中心，研究员/研究组长

研究工作

主要从事渗透胁迫信号传导方面的研究，包括对渗透胁迫上游信号组分的鉴定，以及对ABA调控生长和胁迫应答分子机制的解析等。发现了质膜定位的BON蛋白是渗透胁迫上游信号中的关键组分，提出了渗透与免疫应答拮抗的新概念（Current Biology，2020）；发现渗透胁迫下相分离介导的空间阻隔解除PP2C对第一亚组SnRK2的抑制（Science Advances, 2025），以及酪氨酸磷酸化修饰解除PP2C对第三亚组SnRK2的抑制（EMBO Journal，2024），还发现渗透激活的Ca2+依赖性蛋白激酶CPK3/4/6/11/27介导SnRK2的激活（Developmental Cell, 2025），提出了激酶激活的两步机制：解抑制和激活；阐明了ABA调控干旱下植物根冠比的作用机理（Nature Plants，2022；Cell Reports，2018）；解析了ABA和微管重排调控根尖转换区细胞生长方向改变，介导根尖避盐性（Developmental Cell，2022）。基于这些研究，我们提出渗透信号“复合信号”假说（Journal of Integrative Plant Biology，2024），为继续鉴定渗透信号感受复合体和理解其感受机制提供了线索。

干旱、盐胁迫以及低温等非生物逆境导致的渗透胁迫造成作物生产的巨大损失，是危害我国和世界粮食安全的重要因素之一。渗透胁迫信号传导主要包括信号接收与传导、植物激素脱落酸（ABA）相关调控和后期应答等过程。目前的研究解析了ABA依赖的信号通路，然而对于胁迫信号的接收与传导还知之甚少。我们认为，渗透胁迫的感知可以细分为胁迫造成的生物物理信号的感知，植物可能具有若干条相对独立的胁迫感应机制。本研究组以模式植物拟南芥为研究材料，建立了系统的胁迫早期应答监测体系，结合遗传学、分子生物学、生物化学和细胞生物学，利用Ca2+信号、激酶激活、根避渗性和避盐性等过程，鉴定渗透胁迫早期信号元件，探索植物感知和传导渗透胁迫信号的机制。

主要探究以下三个方面的科学问题：
1. 渗透胁迫造成的哪些生物物理变化可以被植物感知；
2. 植物如何将特定的生物物理信号转变为生物化学信号，如第二信使、激酶激活、蛋白修饰和激素合成等；
3. 生物化学信号如何控制下游的重要表型输出。

主要成果

 

    通讯/第一作者论文 (#第一作者，*通讯作者)
    Publications (# Co-first author, * Corresponding author)

    1. Li Q#, Hu T#, Lu T, Yu B, and Zhao Y*. (2025). Calcium-dependent protein kinases CPK3/4/6/11 and 27 respond to osmotic stress and activate SnRK2s in Arabidopsis. Developmental Cell, accepted.

    2. Yuan X-P. & Zhao Y*. (2025). SnRK2 kinases sense molecular crowding and form condensates to disrupt ABI1 inhibition. Science Advances, accepted.

    3. Li G-J#, Chen K#, Sun S, and Zhao Y*. (2024). Osmotic signaling releases PP2C-mediated inhibition of Arabidopsis SnRK2s via the receptor-like cytoplasmic kinase BIK1. EMBO Journal 43, 6076-6103.

    4. Qin X, Yu B, and Zhao Y*. (2024). Shedding light on hypo-osmotic sensing during pollen rehydration. The Innovation Life 2: 100089.

    5. Yu B, Chao D-Y, and Zhao Y*. (2024). How plants sense and respond to osmotic stress. Journal of Integrative Plant Biology 66, 394-423.

    6. Yu B, Costa A, and Zhao Y*. (2024). Sensing of membrane tensions: the pleiotropic functions of OSCA/TMEM63 mechanosensitive ion channels. Journal of Genetics and Genomics 51, 579-58.

    7. Yu B, Zheng W, Persson S, and Zhao Y*. (2023). Protocol for analyzing root halotropism using split-agar system in Arabidopsis thaliana. STAR Protocols 4, 102157.

    8. Yu B, Zheng W, Xing L, Zhu J-K, Persson S, and Zhao Y*. (2022). Root twisting drives halotropism via stress-induced microtubule reorientation. Developmental Cell 57, 2412-2425.e2416.

    Recommended by Faculty Opinions/F1000: By Prof. Thorsten Hamann. https://facultyopinions.com/article/742367517.

    9. Chen Q, Hu T, Li X, Song C-P, Zhu J-K, Chen L, Zhao Y*. (2022). Phosphorylation of SWEET sucrose transporters regulates plant root:shoot ratio under drought. Nature Plants 8, 68-77.

    Highlighted by Gong, Z., and Yang, S. (2022). Drought meets SWEET. Nature Plants 8, 25-26.

    Recommended by Faculty Opinions/F1000: By Prof. Ekkehard Neuhaus. https://facultyopinions.com/prime/741374069.

    编委推荐，储成才（2022），Nature Plants | 解析干旱胁迫下植物根冠比调控机制，遗传 44 (1), 1-2。

    Highlighted by Fatima U, Anjali A, and Senthil-Kumar M. (2022). AtSWEET11 and AtSWEET12: the twin traders of sucrose. Trends in Plant Science 27, 958-960.

    10. Sun S#, Zhang X#, Chen K, Zhu X, and Zhao Y*. (2021). Screening for Arabidopsis mutants with altered Ca2+ signal response using aequorin-based Ca2+ reporter system. STAR Protocols 2, 100558.

    11. Zhang L#, Wang T#, Wang G, Bi A, Wassie M, Xie Y, Cao L, Xu H, Fu J, Chen L*, Zhao Y*, Hu T*. (2021). Simultaneous gene editing of three homoeoalleles in self-incompatible allohexaploid grasses. Journal of Integrative Plant Biology 63, 1410-1415.

    12. Chen K#, Gao J#, Sun S#, Zhang Z, Yu B, Li J, Xie C, Li G, Wang P, Song CP, Bressan RA, Hua J, Zhu JK*, Zhao Y*. 2020. BONZAI proteins control global osmotic stress responses in plants. Current Biology 30, 4815-4825 e4814.

    Recommended by Faculty Opinions/F1000: Regulators of global osmotic stress responses in plants are not known, and in the present article BON proteins are identified as one of these general regulators. By Prof. Ramón Serrano. https://facultyopinions.com/prime/738803751

    13. Chen K, Li GJ, Bressan RA, Song CP, Zhu JK, Zhao Y*. 2020. Abscisic acid dynamics, signaling, and functions in plants. Journal of Integrative Plant Biology 62(1):25-54. ESI Hot Papers. JIPB’s best invited expert review of the year 2020.

    14. Zhao Y*, Zhang Z#, Gao J#, Wang P#, Hu T#, Wang Z, Hou Y-J, Wan Y, Liu W, Xie S, Lu T, Xue L, Liu Y, Macho AP, Tao WA, Bressan RA, Zhu JK*. (2018). Arabidopsis duodecuple mutant of PYL ABA receptors reveals PYL repression of ABA-independent SnRK2 activity. Cell Reports 23(11), 3340-3351.e5.

    Highlighted by Tena, G. (2018). Stratospheric order mutants. Nature Plants 4, 401.

    15. Wang P#, Zhao Y#, Li Z#, Hsu C-C#, Liu X, Fu L, Hou Y-J, Du Y, Xie S, Zhang C, Gao J, Cao M, Huang X, Zhu Y, Tang K, Wang X, Tao WA, Xiong Y*, Zhu JK*. 2018. Reciprocal regulation of the TOR kinase and ABA receptor balances plant growth and stress response. Molecular Cell 69(1):100-112 e106. ESI Highly Cited Papers. Recommended by F1000.

    Highlighted by Rosenberger, C.L., and Chen, J. (2018). To Grow or Not to Grow: TOR and SnRK2 Coordinate Growth and Stress Response in Arabidopsis. Molecular Cell 69, 3-4.

    16. Wang YG#, Fu FL#, Yu HQ#, Hu T, Zhang YY, Tao Y, Zhu JK, Zhao Y*, Li WC*. 2018. Interaction network of core ABA signaling components in maize. Plant Molecular Biology 96, 245-263.

    17. Zhao Y*, Gao J, Kim JI, Chen K, Bressan RA, Zhu JK. (2017). Control of plant water use by ABA induction of senescence and dormancy: an overlooked lesson from evolution. Plant and Cell Physiology 58, 1319-1327.

    18. Zhao Y#, Chan Z#, Gao J, Xing L, Cao M, Yu C, Hu Y, You J, Shi H, Zhu Y, Gong Y, Mu Z, Wang H, Deng X, Wang P, Bressan RA, Zhu JK*. (2016). The ABA receptor PYL9 promotes drought resistance and leaf senescence. Proceedings of the National Academy of Sciences of the United States of America 113, 1040-1954. ESI Highly Cited Papers.

    19. Xing L#, Zhao Y#, Gao J#, Xiang C*, Zhu JK*. (2016). The ABA receptor PYL9 together with PYL8 plays an important role in regulating lateral root growth. Scientific Reports 6, 27177.

    20. Zhao Y#, Xing L#, Wang X, Hou YJ, Gao J, Wang P, Duan CG, Zhu X, and Zhu JK*. (2014). The ABA receptor PYL8 promotes lateral root growth by enhancing MYB77-dependent transcription of auxin-responsive genes. Science Signaling 7, ra53. Cover story.

    Highlighted by BERNDT, J. D. 2014. ABA tells roots to stop and then grow. Science, 344, 1128-1128.

    21. Zhao Y#, Chan Z#, Xing L, Liu X, Hou YJ, Chinnusamy V, Wang P, Duan C, and Zhu JK*. (2013). The unique mode of action of a divergent member of the ABA-receptor protein family in ABA and stress signaling. Cell Research 23, 1380-1395.

    22. Ge B#, Yang DH#, Zhao Y#, Ha S, Yang F, Ma J, Gao XS, Wang ZM*, and Zhu JK*. (2013). Interactions between soybean ABA receptors and type 2C protein phosphatases. Plant Molecular Biology 83, 651-664. Cover story.

    23. Zhao Y#, Zhao S, Mao T, Qu X, Cao W, Zhang L, Zhang W, He L, Li S, Ren S, Zhao J, Zhu G, Huang S, Ye K, Yuan M, and Guo Y*. (2011). The plant-specific actin binding protein SCAB1 stabilizes actin filaments and regulates stomatal movement in Arabidopsis. Plant Cell 23: 2314-2330.

    24. 于波, 秦晓惠, 赵杨*. 植物感应干旱信号的机制. 生物技术通报, 2023, 39(11): 6-17.

    25. 赵杨, 杨永青, 丁杨林, 张蘅, 谢彦杰, 赵春钊, 刘林川, 王鹏程*. 植物非生物逆境学科发展综述. 植物生理学报, 2024, 60(2): 248-270.

    合作作者论文：

    1, Colin L, Ruhnow F, Zhu J-K, Zhao C, Zhao Y, and Persson S. (2023). The cell biology of primary cell walls during salt stress. Plant Cell 35, 201-217.

    2. Hu Y, Ding Y, Cai B, Qin X, Wu J, Yuan M, Wan S, Zhao Y, and Xin X-F*. (2022). Bacterial effectors manipulate plant abscisic acid signaling for creation of an aqueous apoplast. Cell Host & Microbe 30, 518-529.e516.

    3. Yang Y#, Zhao Y#, Zheng W#, Zhao Y, Zhao S, Wang Q, Bai L, Zhang T, Huang S, Song C, Yuan M, Guo Y*. (2022). Phosphatidylinositol 3-phosphate regulates SCAB1-mediated F-actin reorganization during stomatal closure in Arabidopsis. Plant Cell 34, 477-494.

    4. Chen B, Fiers M, Dekkers B.J.W., Maas L, van Esse G.W., Angenent G.C., Zhao Y, and Boutilier K*. (2021). ABA signalling promotes cell totipotency in the shoot apex of germinating embryos. J Exp Bot 72, 6418-6436.

    5. Yang J, He H, He Y, Zheng Q, Li Q, Feng X, Wang P, Qin G, Gu Y, Wu P, Peng C, Sun S, Zhang Y, Wen M, Chen R, Zhao Y, Xu T*. (2021). TMK1-based auxin signaling regulates abscisic acid responses via phosphorylating ABI1/2 in Arabidopsis. Proc Natl Acad Sci U S A 118.

    6. Zhang H*, Zhao Y, Zhu JK*. 2020. Thriving under stress: how plants balance growth and the stress response. Developmental Cell 55(5), 529-543.

    7. Zhao C#*, Jiang W#, Zayed O#, Liu X, Tang K, Nie W, Li Y, Xie S, Li Y, Long T, Liu L, Zhu Y, Zhao Y, Zhu JK*. 2020. The LRXs-RALFs-FER module controls plant growth and salt stress responses by modulating multiple plant hormones. National Science Review, nwaa149, https://doi.org/10.1093/nsr/nwaa149.

    8. Qu M, Essemine J, Xu J, Ablat G, Perveen S, Wang H, Chen K, Zhao Y, Chen G*, Chu C*, Zhu X*. 2020. Alterations in stomatal response to fluctuating light increase biomass and yield of rice under drought conditions. Plant Journal 104: 1334-1347.

    9. Wang Z#, Ren Z#, Cheng C#, Wang T#, Ji H, Zhao Y, Deng Z, Zhi L, Lu J, WuX, Xu S, Cao M, Zhao H, Liu L, Zhu JK, Li X*. 2020. Counteraction of ABA-mediated inhibition of seed germination and seedling establishment by ABA signaling terminator in Arabidopsis. Molecular Plant 13(9):1284-1297.

    10. Lin Z#, Li Y#, Zhang Z#, Liu X#, Hsu CC, Du Y, Sang T, Zhu C, Wang Y, Satheesh V, Pratibha P, Zhao Y, Song CP, Tao WA, Zhu JK*, Wang P*. 2020. A RAF-SnRK2 kinase cascade mediates early osmotic stress signaling in higher plants. Nature Communications 11(1):613. Recommended by F1000.

    11. Maggio A, Bressan RA, Zhao Y, Park J, Yun D-J*. 2018. It’s hard to avoid avoidance: uncoupling the evolutionary connection between plant growth, productivity and stress “tolerance”. International Journal of Molecular Sciences 19, 3671.

    12. Miao C, Xiao L, Hua K, Zou C, Zhao Y, Bressan RA, and Zhu JK*. 2018. Mutations in a subfamily of abscisic acid receptor genes promote rice growth and productivity. Proceedings of the National Academy of Sciences of the United States of America 115, 6058-6063. ESI Highly Cited Papers.

    13. Wang K#, He J#, Zhao Y, Wu T, Zhou X, Ding Y, Kong L, Wang X, Wang Y, Li J, Song CP, Wang BS, Yang SH, Zhu JK, Gong ZZ*. 2018. EAR1 negatively regulates ABA signaling by enhancing 2C protein phosphatase activity. Plant Cell 30, 815-834.

    14. Yan J#, Wang P#, Wang B, Hsu C-C, Tang K, Zhang H, Hou Y-J, Zhao Y, Wang Q, Zhao C, Zhu X, Tao WA, Li J, Zhu JK*. 2017. The SnRK2 kinases modulate miRNA accumulation in Arabidopsis. PLOS Genetics 13, e1006753.

    15. Zhao, S., Jiang, Y., Zhao, Y., Huang, S., Yuan, M., Zhao, Y., Guo, Y.* (2016) Casein kinase1-like protein2 controls actin filament stability and stomatal closure via phosphorylation of actin depolymerizing factor. Plant Cell 28, 1422-1439.

    16. Hou, Y.J.#, Zhu, Y.#, Wang, P.#, Zhao, Y., Xie, S., Batelli, G., Wang, B., Duan, C., Wang, X., Xing, L., Lei M., Zhu X., Zhu J.K.* (2016). Type One Protein Phosphatase 1 (TOPP1) and its regulatory protein Inhibitor 2 (AtI-2) negatively regulate ABA signaling. PLOS Genetics 12, e1005835.

    17. Lind, C.#, Dreyer, I.#, Lopez-Sanjurjo, E.J., von Meyer, K., Ishizaki, K., Kohchi, T., Lang, D., Zhao, Y., Kreuzer, I., Al-Rasheid, K.A., Ronne, H., Reski, R., Zhu, J.K., Geiger, D.*, Hedrich, R. (2015). Stomatal guard cells co-opted an ancient ABA-dependent desiccation survival system to regulate stomatal closure. Current Biology 25, 928-935.

    18. Wang, P.#, Du, Y.#, Hou, Y.J., Zhao, Y., Hsu, C.C., Yuan, F., Zhu, X., Tao, W.A., Song, C.P., and Zhu, J.K.* (2015). Nitric oxide negatively regulates abscisic acid signaling in guard cells by S-nitrosylation of OST1. Proceedings of the National Academy of Sciences of the United States of America 112, 613-618. ESI Highly Cited Papers.

    19. Wang, C., Zheng, Y., Zhao, Y., Zhao, Y., Li, J., and Guo, Y.* (2015). SCAB3 Is Required for Reorganization of Actin Filaments during Light Quality Changes. Journal of Genetics and Genomics 42, 161-168.

    20. Zhou, X., Hao, H., Zhang, Y., Bai, Y., Zhu, W., Qin, Y., Yuan, F., Zhao, F., Wang, M., Hu, J., Xu, H., Guo, A., Zhao, H., Zhao, Y., Cao, C., Yang, Y., Schumaker, K.S., Guo, Y., Xie, C.G.* (2015). SOS2-LIKE PROTEIN KINASE5, an SNF1-RELATED PROTEIN KINASE3-Type Protein Kinase, Is Important for Abscisic Acid Responses in Arabidopsis through Phosphorylation of ABSCISIC ACID-INSENSITIVE5. Plant Physiology 168, 659-676.

    21. Duan, C.G.#, Zhang, H.#, Tang, K.#, Zhu, X., Qian, W., Hou, Y.J., Wang, B., Lang, Z., Zhao, Y., Wang, X., Wang, P., Zhou, J., Liang, G., Liu, N., Wang, C., Zhu, J.K.* (2015). Specific but interdependent functions for Arabidopsis AGO4 and AGO6 in RNA-directed DNA methylation. The EMBO journal 34, 581-592.

    22. Sridharamurthy, M., Kovach, A., Zhao, Y., Zhu, J.K., Xu, H.E., Swaminathan, K.*, and Melcher, K.* (2014). H2O2 Inhibits ABA-Signaling Protein Phosphatase HAB1. PLoS One 9, e113643.

    23. Liu X., Zhang H., Zhao Y., Feng Z., Li Q., Yang H-Q., Luan S., Li J., He Z-H.* (2013). Auxin controls seed dormancy through stimulation of abscisic acid signaling by inducing ARF-mediated ABI3 activation in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America 110 (38):15485-90. ESI Highly Cited Papers.

    24. Wang X.#, Duan C-G.#, Tang K., Wang B., Zhang H., Lei M., Lu K., Mangrauthia S-K., Wang P., Zhu G., Zhao Y., Zhu J-K.* (2013). An RNA-binding protein regulates plant DNA methylation by controlling mRNA processing at intronic heterochromatin-containing genes. Proceedings of the National Academy of Sciences of the United States of America 110 (38):15467-72.

    25. Cao M.#, Liu X.#, Zhang Y., Xue X., Zhou X-E., Melcher K., Gao P., Wang F., Zeng L., Zhao Y., Zhao Y., Deng P., Zhong D., Zhu J-K.*, Xu H-E.*, and Xu Y.* (2013) An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants. Cell Research 23:1043–1054.

    26. Zhang W., Zhao Y., Guo Y., and Ye K.* (2012). Plant actin-binding protein SCAB1 is dimeric actin cross-linker with atypical pleckstrin homology domain. The Journal of Biological Chemistry 287, 11981-11990.

    27. Pan Z., Zhao Y., Zheng Y., Liu J., Jiang X., Guo Y.* (2012). A high-throughput method for screening Arabidopsis mutants with disordered abiotic stress-induced calcium signal. Journal of Genetics and Genomics 39(5): 225-235.

    28. Yang Y., Zhao Y., Zhu G.* (2011). pH induced elastic modulus of guard cell wall in stomatal movement. Chinese Science Bulletin 56:3554-3557.

    29. Zhao J., Zhang W., Zhao Y., Gong X., Guo L., Zhu G., Wang X., Gong Z., Schumaker K.S., and Guo Y.* (2007). SAD2, an importin -like protein, is required for UV-B response in Arabidopsis by mediating MYB4 nuclear trafficking. Plant Cell 19: 3805-3818.