首页　　 人才队伍
个人信息

博士生导师
研究员

Email: junxu@cemps.ac.cn
个人网页:

研究方向

昆虫器官发育与通讯

许军

个人简介

2008.9-2012.7 广西大学林学系，学士
2012.9-2017.6 中国科学院上海生命科学研究院植物生理生态研究所，博士
2017.7-2019.8 中国科学院分子植物科学卓越创新中心, 博士后
2019.9-2022.10 哈佛大学遗传学系, 博士后
2022.10-至今 中国科学院分子植物科学卓越创新中心，研究员

研究工作

器官发育及稳态调控是个体生存的基础。昆虫器官发育的研究不仅可以揭示动物发育生物学的普遍性调控机制，还可以用来建立人类疾病模型以及发现新的害虫遗传治理方式。器官发育及稳态调控依赖器官本身的精细基因调控及器官间的交流互作。本课题组未来的研究将会以果蝇为模式，并结合家蚕和稻纵卷叶螟开展昆虫器官发育、代谢与交流方向的研究。以开发基因和蛋白质操控的新技术新方法为手段，解析昆虫重要器官（如丝腺、肾脏等）发育和调控的遗传机制。具体研究方向如下：
1）磷代谢与细胞器互作；
2）器官发育与器官间通讯调控；
3）基因表达和蛋白质操控新技术研究；
4）农业害虫遗传控制。

主要成果

    1. Jun Xu#, *, Ying Liu#, *, Fangying Yang, Yurou Cao, Weihang Chen, Joshua Shing Shun Li, Shuai Zhang, Aram Comjean, Yanhui Hu, Norbert Perrimon*. Mechanistic characterization of a Drosophila model of paraneoplastic nephrotic syndrome. Nature Communications. 2024, 15(1):1241.

    2. Chiwei Xu#, *, Jun Xu#, Hong-Wen Tang, Jui-Hsia Weng, Maria Ericsson, Jonathan DiRusso, Yanhui Hu, Wenzhe Ma, John M. Asara, Norbert Perrimon*. A phosphate-sensing organelle regulates phosphate storage and tissue homeostasis. Nature. 2023, 617(7962):798-806

    3. Jun Xu#, Yifang Liu#, Hongjie Li, Alexander J. Tarashansky, Colin H. Kalicki, Ruei-Jiun Hung, Yanhui Hu, Aram Comjean, Sai Saroja Kolluru, Bo Wang, Stephen R Quake, Liqun Luo, Andrew P. McMahon, Julian A.T. Dow, Norbert Perrimon. Transcriptional and functional motifs defining renal function revealed by single nuclear sequencing. PNAS. 2022, 119(25): e2203179119.

    4. Jun Xu#, Qinglin Dong#, Ye Yu, Baolong Niu, Dongfeng Ji, Muwang Li, Yongping Huang, Xin Chen, Anjiang Tan. Mass spider silk production through targeted gene replacement in Bombyx mori. PNAS. 2018, 115(35): 8757–8762.

    5. Jun Xu#, *, Ah-Ram Kim#, Ross W. Cheloha, Fabian A. Fischer, Joshua Shing Shun Li, Yuan Feng, Emily Stoneburner, Richard Binari, Stephanie E. Mohr, Jonathan Zirin, Hidde Ploegh, Norbert Perrimon*. Protein visualization and manipulation in Drosophila through the use of epitope tags recognized by nanobodies. eLife. 2022, 11, e74326.

    6. Ben Ewen-Campen#, Haojiang Luan#, Jun Xu#, Rohit Singh#, Neha Joshi, Tanuj Thakkar, Bonnie Berger, Benjamin H White, Norbert Perrimon. split-intein Gal4 provides intersectional genetic labeling that is repressible by Gal80. PNAS. 2023, 20(24): e2304730120.

    7. Jun Xu, Xia Xu, Shuai Zhan, Yongping Huang. Genome editing in insects: Current status and challenges. National Science Review. 2019, 6: 399–401.

    8. Ah-Ram Kim#, Jun Xu#, *, Ross Cheloha, Stephanie E Mohr, Jonathan Zirin, Hidde L Ploegh, Norbert Perrimon*. Nanotag-Nanobody tools for Drosophila in vitro and in vivo studies. Current Protocol. 2022, 2(12): e628.

    9. Jun Xu#, Wei Liu#, Dehong Yang, Shuqing Chen, Kai Chen, Zulian Liu, Xu Yang, Jing Meng, Guanheng Zhu, Shuanglin Dong, Yong Zhang, Shuai Zhan, Guirong Wang*, Yongping Huang*. Regulation of olfactory-based sex behaviors in the silkworm by genes in the sex-determination cascade. PLoS Genetics. 2020,16(6): e1008622. 2(12):e628.

    10. Jun Xu, Shuqing Chen, Baosheng Zeng, Anthony A. James, Anjiang Tan, Yongping Huang. Bombyx mori P-element somatic inhibitor (BmPSI) is a key auxiliary factor for silkworm male sex determination. PLoS Genetics. 2017, 13(1): e1006576.

    11. Kai Chen, Ye Yu, Dehong Yang, Xu Yang, Linmeng Tang, Yujia Liu, Xingyu Luo, James R Walter, Zulian Liu, Jun Xu*, Yongping Huang*. Gtsf1 is essential for proper female sex determination and transposon silencing in the silkworm, Bombyx mori. PLoS Genetics. 2020, 16(11): e1009194.

    12. Shuqing Chen, Yujia Liu, Xu Yang, Zulian Liu, Xingyu Luo, Jun Xu*, Yongping Huang*. Dysfunction of dimorphic sperm impairs male fertility in the silkworm. Cell Discovery. 2020, 6: 60.

    13. Zulian Liu, Jun Xu*, Lin Ling, Dehong Yang, Shuqing Chen, Yongping Huang. MicroRNA-2738 regulates gene expression in the sex determination pathway in Bombyx mori. Insect Science. 2020, 27(4): 646–654.

    14. Honglun Bi, Xia Xu, Xiaowei Li, Yong Zhang, Yongping Huang, Kai Li*, Jun Xu*. CRISPR Disruption of BmOvo Resulted in the Failure of Emergence and Affected the Wing and Gonad Development in the Silkworm Bombyx mori. Insects. 2019, 10(8). pii: E254.

    15. Jun Xu#, Ye Yu#, Kai Chen, Yongping Huang. Intersex regulates female. external genital and imaginal disc development in the silkworm. Insect Biochemistry and Molecular Biology. 2019, 108: 1–8.

    16. Jun Xu#, Rongmei Chen#, Shuqing Chen, Kai Chen, Linmeng Tang, Dehong. Yang, Xu Yang, Yong Zhang, Hongsheng Song, Yongping Huang. Identification of a germline-expression promoter for genome editing in Bombyx mori. Insect Science. 2019, 26(6): 991–999.

    17. Jun Xu, Shuai Zhan, Shuqing Chen, Baosheng Zeng, Zhiqian Li, Anthony A. James, Anjiang Tan, Yongping Huang. Sexually dimorphic traits in the silkworm, Bombyx mori, are regulated by doublesex. Insect Biochemistry and Molecular Biology. 2017, 80: 42–51.

    18. Jun Xu, Honglun Bi, Rongmei Chen, Abu F.M. Aslam, Zhiqian Li, Lin Ling, Baosheng Zeng, Yongping Huang, Anjiang Tan. Transgenic characterization of two testis-specific promoters in the silkworm, Bombyx mori. Insect Molecular Biology. 2015, 24(2): 183–190.

    19. Jun Xu, Yueqiang Wang, Zhiqian Li, Lin Ling, Baosheng Zeng, Anthony A. James, Anjiang Tan, Yongping Huang. Transcription activator-like effector nuclease (TALEN)-mediated female-specific sterility in the silkworm, Bombyx mori. Insect Molecular Biology. 2014, 23(6): 800–807.

    20. Jun Xu, Yueqiang Wang, Zhiqian Li, Lin Ling, Baosheng Zeng, Lang You, Yazhou Chen, Abu F.M. Aslam, Yongping Huang, Anjiang Tan. Functional characterization of the vitellogenin promoter in the silkworm, Bombyx mori. Insect Molecular Biology. 2014, 23(5): 550–557.

    21. Dehong Yang, Jun Xu, Kai Chen, Yujia Liu, Xu Yang, Linmeng Tang, Xingyu Luo, Zulian Liu, Muwang Li, James R Walters, Yongping Huang. BmPMFBP1 regulates the development of eupyrene sperm in the silkworm, Bombyx mori. PLoS Genetics. 2022, 18(3): e1010131.

    22. Hongjie Li, et al., Jun Xu, et al., Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly. Science, 2022, 375(6584): eabk2432.

    23. Stephanie E Mohr, Sudhir Gopal Tattikota, Jun Xu, Jonathan Zirin, Yanhui Hu, Norbert Perrimon. Methods and tools for spatial mapping of single-cell RNAseq clusters in Drosophila. Genetics. 2021, 217(4): iyab019.

    24. Hong-Wen Tang, Jui-Hsia Weng, Wen Xing Lee, Yanhui Hu, Lei Gu, Sungyun Cho, Gina Lee, Richard Binari, Cathleen Li, Min En Cheng, Ah-Ram Kim, Jun Xu, Zhangfei Shen, Chiwei Xu, John M Asara, John Blenis, Norbert Perrimon. mTORC1-chaperonin CCT signaling regulates m6A RNA methylation to suppress autophagy. PNAS. 2021, 118(10): e2021945118.

    25. Zulian Liu, Jun Xu, Lin Ling, Xingyu Luo, Dehong Yang, Xu Yang, Xiaoqian Zhang, Yongping Huang. miR-34 regulates larval growth and wing morphogenesis by directly modulating ecdysone signalling and cuticle protein in Bombyx mori. RNA Biology. 2020, 17(9): 1342–1351.

    26. Xia Xu, Yaohui Wang, Honglun Bi, Jun Xu, Zulian Liu, Changying Niu, Lin He, Anthony A.James, Kai Li, Yongping Huang. Mutation of the seminal protease gene, serine protease 2, results in male sterility in diverse lepidopterans. Insect Biochemistry and Molecular Biology. 2020, 116: 103243.

    27. Shuai Zhan#, Gangqi Fang#, Minmin Cai#, Zongqing Kou#, Jun Xu, Yanghui Cao, Liang Bai, Yixiang Zhang, Yongmao Jiang, Xingyu Luo, Jian Xu, Xia Xu, Longyu Zheng, Ziniu Yu, Hong Yang, Zhijian Zhang, Sibao Wang, Jeffery K. Tomberlin, Jibin Zhang & Yongping Huang. Genomic landscape and genetic manipulation of the black soldier fly Hermetia illucens, a natural waste recycler. Cell Research. 2019, 30(1): 50–60.

    28. Yaohui Wang, Xi'en Chen, Zulian Liu, Jun Xu, Xiaowei Li, Honglun Bi, Awawing A. Andongma, Changying Niu, Yongping Huang. Mutation of doublesex induces sex-specific sterility of the diamondback moth Plutella xylostella. Insect Biochemistry and Molecular Biology. 2019, 112: 103180.

    29. Kai Chen, Shuqing Chen, Jun Xu, Ye Yu, Zulian Liu, Anjiang Tan, & Yongping Huang. Maelstrom regulates spermatogenesis of the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology. 2019, 109: 43–51.

    30. Zulian Liu, Lin Ling, Jun Xu, Baosheng Zeng, Yongping Huang, Peng Shang, Anjiang Tan. MicroRNA-14 regulates larval development time in Bombyx mori. Insect Biochemistry and Molecular Biology. 2018, 93: 57–65.

    31. Shuqing Chen*, Chengxiang Hou*, Honglun Bi, Yueqiang Wang, Jun Xu, Muwang Li, Anthony A. James, Yongping Huang, Anjiang Tan. Transgenic Clustered Regularly Interspaced Short Palindromic Repeat/Cas9-Mediated Viral Gene Targeting for Antiviral Therapy of Bombyx mori Nucleopolyhedrovirus. Journal of Virology. 2017, 91(8). pii: e02465–16.

    32. Baosheng Zeng, Yuping Huang, Jun Xu, Takahiro Shiotsuki, Hua Bai, Subba Reddy Palli, Yongping Huang, Anjiang Tan. The FOXO transcription factor controls insect growth and development by regulating juvenile hormone degradation in the silkworm, Bombyx mori. Journal of Biological Chemistry. 2017, 292(28): 11659–11669.

    33. Baosheng Zeng, Shuai Zhan, Yueqiang Wang, Yuping Huang, Jun Xu, Qun Liu, Zhiqian Li, Yongping Huang, Anjiang Tan. Expansion of CRISPR targeting sites in Bombyx mori. Insect Biochemistry and Molecular Biology. 2016, 72: 31–40.

    34. Guanheng Zhu, Jun Xu, Zhen Cui, Xiaotong Dong, Zhanfeng Ye, Dongjuan Niu, Yongping Huang, Shuanglin Dong. Functional characterization of SlitPBP3 in Spodoptera litura by CRISPR/Cas9 mediated genome editing. Insect Biochemistry and Molecular Biology. 2016, 75: 1–9.

    35. Lin Ling, Xie Ge, Zhiqian Li, Baosheng Zeng, Jun Xu, Xu Chen, Peng Shang, Anthony A. James, Yongping Huang, Anjiang Tan. MiR-2 family targets awd and fng to regulate wing morphogenesis in Bombyx mori. RNA Biology. 2015, 12(7): 742–748.

    36. Zhiqian Li, Lang You, Baosheng Zeng, Lin Ling, Jun Xu, Xu Chen, Zhongjie Zhang, SR Palli, Yongping Huang, Anjiang Tan. Ectopic expression of ecdysone oxidase impairs tissue degeneration in Bombyx mori. Proceedings of the Royal Society B-Biological Sciences. 2015, 282(1809): 20150513.

    37. Zhiqian Li, Xie Ge, Lin Ling, Baosheng Zeng, Jun Xu, Abu F.M. Aslam, Lang You, SR Palli, Yongping Huang, Anjiang Tan. CYP18A1 regulates tissue-specific steroid hormone inactivation in Bombyx mori. Insect Biochemistry and Molecular Biology. 2014, 54: 33–41.

    38. Lin Ling, Xie Ge, Zhiqian Li, Baosheng Zeng, Jun Xu, Abu F.M. Aslam, Qisheng Song, Peng Shang, Yongping Huang, Anjiang Tan. MicroRNA Let-7 regulates molting and metamorphosis in the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology. 2014, 53: 13–21.

    39. Yazhou Chen, Muwang Li, Iftakher Islam, Lang You, Yueqiang Wang, Zhiqian Li, Lin Ling, Baosheng Zeng, Jun Xu, Yongping Huang, Anjiang Tan. Allelic-specific Expression in Relation to Bombyx mori resistance to Bt toxin. Insect Biochemistry and Molecular Biology. 2014, 54: 53–60.

    40. Yueqiang Wang*, Anjiang Tan*, Jun Xu, Zhiqian Li, Baosheng Zeng, Lin Ling, Lang You, Yazhou Chen, Anthony A. James, Yongping Huang. Site-specific, TALENs-mediated transformation of Bombyx mori. Insect Biochemistry and Molecular Biology. 2014, 55: 26–30.

    41. Yueqiang Wang, Zhiqian Li, Jun Xu, Baosheng Zeng, Lin Ling, Lang You, Yazhou Chen, Yongping Huang, Anjiang Tan. The CRISPR/Cas system mediates efficient genome engineering in Bombyx mori. Cell Research. 2013, doi: 10.1038/cr.2013.146.