王超
个人简介
2024.10-至今 中国科学院分子植物科学卓越创新中心 研究员
2017.12-2024.09 加州大学伯克利分校 博士后/项目科学家(唐氏杰出学者)
2015.06-2017.06 中国科学院分子植物科学卓越创新中心 博士后
2009.09-2015.06 华中农业大学 博士
2006.09-2009.06 华中农业大学 学士
研究工作
在农业研究中,一方面科学家致力于研究豆科植物与根瘤菌的互惠共生,探索根瘤菌入侵并稳定定殖豆科植物的机理。另一方面,科学家广泛而深入地研究植物先天免疫系统,以期望理解植物如何抵抗病原菌入侵和定殖。两个方面的研究对于农业和经济的潜力提升都非常关键。在农业实践中,科学家需要面对一个基本事实:一旦庄稼生长在土壤中,植物除了与包括互惠和竞争的微生物持续的相互作用,还要应对土壤矿物质(氮、磷、钾、钙、镁、铁等)不均衡和其他各种非生物胁迫。其中钙离子作为矿质营养,同时又作为重要的第二信使,几乎参与了所有的生物学信号过程,其中也包括矿质元素的吸收,并在植物免疫和豆科植物共生中起着核心的信号传递作用。因此,植物免疫,豆科共生,钙信号及其它矿质元素协调作用的研究应得到植物科学界重视。充分理解其机理,有望在未来农业生产中得到应用。
课题组将基于钙生物学研究,以多种植物(豆科植物及拟南芥)为研究对象,围绕植物免疫、共生固氮和土壤矿质营养吸收开展一系列相关联的工作:
1)钙稳态/钙信号驱动的植物“生长—免疫”平衡。
2)豆科植物与根瘤菌共生体系中的免疫稳态。
3)钙稳态/钙信号驱动的豆科矿质元素吸收和高效固氮。
主要成果
Wang C*, Tang R-J*,Kou S, Xu X, Lu Y, Rauscher K, Voelker A, Luan S. (2024). Mechanisms of calcium homeostasis orchestrate plant growth and immunity. Nature. 627(8003):382-388.
Liu F*, Yang Z*, Wang C, You Z, Martin R, Qiao W, Huang J, Jacob P, Dangl J, Carette J, Luan S, Nogales E, Staskawicz B. (2024).Activation of the helper NRC4 immune receptor forms a hexameric resistosome. Cell. 187(18):4877-4889. e15
Gao Q*, Wang C*, Xi Y, Shao Q, Hou C, Li L, Luan S. (2023). RALF signaling pathway activates MLO calcium channels to maintain pollen tube integrity. Cell research: 1-9.
Gao Q, Wang C, Xi Y, Shao Q, Li L, Luan S. (2022). A receptor-channel trio conducts Ca2+ signaling for pollen tube reception. Nature 607: 534-539.
Tian W*, Hou C*, Ren Z*, Wang C*, Zhao F, Dahlbeck D, Hu S, Zhang L, Niu Q, Li L, Staskawicz B. J, Luan S (2019). A calmodulin-gated calcium channel links pathogen patterns to plant immunity. Nature572(7767): 131-135.
Wang C*, Wang G*, Zhang C, Zhu P, Dai H, He Z, Xu L, Wang E (2017). OsCERK1-mediated chitin perception and immune signaling requires Receptor-like Cytoplasmic Kinase185 to activate an MAPK cascade in rice. Molecular Plant10:619-633.
Wang C, Yu H, Luo L, Duan L, Cai L, He X, Wen J, Mysore KS, Li G, Xiao A, Duanmu D, Cao Y, Hong Z, Zhang Z (2016). NODULES WITH ACTIVATED DEFENSE 1 is required for maintenance of rhizobial endosymbiosis in Medicago truncatula. New Phytologist212: 176-191.
Wang C, Xu X, Hong Z, Feng Y, Zhang Z (2015). Involvement of ROP6 and clathrin in nodulation factor signaling. Plant Signaling & Behavior10: e1033127.
Wang C*, Zhu M*, Duan L, Yu H, Chang X, Li L, Kang H, Feng Y, Zhu H, Hong Z, Zhang Z (2015). Lotus japonicus clathrin heavy chain1 is associated with Rho-Like GTPase ROP6 and involved in nodule formation. Plant Physiology167: 1497-1510.
Wang C, Yu H, Zhang Z, Yu L, Xu X, Hong Z, Luo L. (2015). Phytosulfokine is involved in positive regulation of Lotus japonicus nodulation. Molecular Plant-Microbe Interactions28: 847-855.
Wang C*, Zhu H*, Jin L, Chen T, Wang L, Kang H, Hong Z, Zhang Z (2013). Splice variants of the SIP1 transcripts play a role in nodule organogenesis in Lotus japonicus.Plant Molecular Biology 82: 97-111.
综述:
Wang C, Luan S. (2024). Calcium homeostasis and signaling in plant immunity. Curr Opinion Plant Biol77:102485.
Luan S, Wang C. (2021). Calcium signaling mechanisms across kingdoms. Annu Rev Cell Dev Biol. 37:311-340.
Tang R-J, Wang C, Li K, Luan S. (2020). The CBL–CIPK Calcium Signaling Network: Unified Paradigm from 20 Years of Discoveries. Trends Plant Sci25, 604-617.
Tian W*, Wang C*, Gao Q, Li L, Luan S. (2020). Calcium spikes, waves, and oscillations in plant development and biotic interactions. Nature Plants6: 750-759.
Wang C, Wang E (2016). (Commentary) Arabidopsis farms Colletotrichum tofieldiae for phosphate uptake. Molecular Plant9: 953-955.
其它:
Yu H, Xiao A, Zou Z, Wu Q, Chen L, Zhang D, Sun Y, Wang C, Cao J, Zhu H, Zhang Z, Cao Y. (2024). Conserved cis-elements enable NODULES WITH ACTIVATED DEFENSE1 regulation by NODULE INCEPTION during nodulation. The Plant Cell. 36(10):4622-4636.
Li K, Tang R-J, Wang C, Luan S. (2023). Potassium nutrient status drives posttranslational regulation of a low-K response network in Arabidopsis. Nature Communications14 (1): 360.
Tang R-J, Meng S, Zheng X, Zhang B, Yang Y, Wang C, Fu A-G, Zhao F-G, Lan W-Z, Luan S (2022). Conserved mechanism for vacuolar magnesium sequestration in yeast and plant cells. Nature Plant8: 181-190.
Tang R-J, Yang Y, Yan Y, Mao D, Yuan H, Wang C, Zhao F-G, Luan S (2022). Two transporters mobilize magnesium from vacuolar stores to enable plant acclimation to magnesium deficiency. Plant Physiology190: 1307-1320.
Lhamo D, Wang C, Gao Q, Luan S (2021). Recent Advances in Genome-wide Analyses of Plant Potassium Transporter Families. Curr Genomics22: 164-180.
Feng Y, Wu P, Liu C, Peng L, Wang T, Wang C, Tan Q, Li B, Ou Y, Zhu H, et.al. (2021). Suppression of LjBAK1-mediated immunity by SymRK promotes rhizobial infection in Lotus japonicas.Molecular Plant14: 1935-1950.
Zhang C, He J, Dai H, Wang G, Zhang X, Wang C, Shi J, Chen X, Wang D, Wang E (2021). Discriminating symbiosis and immunity signals by receptor competition in rice. Proc Natl Acad Sci U S A118.
Tang R-J, Zhao F-G, Yang Y, Wang C, Li K, Kleist TJ, Lemaux PG, Luan S (2020). A calcium signalling network activates vacuolar K+ remobilization to enable plant adaptation to low-K environments. Nature Plants6: 384-393
Tang R-J, Luan M, Wang C, Lhamo D, Yang Y, Zhao F-G, Lan W-Z, Fu A-G, Luan S (2020). Plant Membrane Transport Research in the Post-genomic Era. Plant Communications1 (1):100013.
Xiao A, Yu H, Fan Y, Kang H, Ren Y, Huang X, Gao X, Wang C, Zhang Z, Zhu H, and Cao Y. (2020). Transcriptional regulation of NIN expression by IPN2 is required for root nodule symbiosis in Lotus japonicus. New phytologist227 (2): 513-528.
Yu H*, Wang C*, Cai L, Huang B, Zhang Z (2020). Functional dissection of Medicago truncatula NODULES WITH ACTIVATED DEFENSE 1 in maintenance of rhizobial endosymbiosis. The Model Legume Medicago Truncatula, chapter 9.2.4.
Yu H, Xiao A, Dong R, Fan Y, Zhang X, Liu C, Wang C, Zhu H, Duanmu D, Cao Y, Zhang Z (2018). Suppression of innate immunity mediated by the CDPK-Rboh complex is required for rhizobial colonization in Medicago truncatula nodules. New phytologist220 (2): 425-434.
Jin Y, Liu H, Luo D, Yu N, Dong W, Wang C, Zhang X, Dai H, Yang J, Wang E (2016). DELLA proteins are common components of symbiotic rhizobial and mycorrhizal signalling pathways. Nature Communications7: 12433.
Kang H, Chu X, Wang C, Xiao A, Zhu H, Yuan S, Yang Z, Ke D, Xiao S, Hong Z, Zhang Z (2014). A MYB coiled-coil transcription factor interacts with NSP2 and is involved in nodulation in Lotus japonicus. New Phytologist201: 837-849.
Chen T, Zhu H, Ke D, Cai K, Wang C, Gou H, Hong Z, Zhang Z (2012). A MAP kinase kinase interacts with SymRK and regulates nodule organogenesis in Lotus japonicus. The Plant Cell24: 823-838.
Kang H, Zhu H, Chu X, Yang Z, Yuan S, Yu D, Wang C, Hong Z, Zhang Z (2011). A novel interaction between CCaMK and a protein containing the Scythe_N ubiquitin-like domain in Lotus japonicus. Plant Physiology155: 1312-1324.