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Email: dlyang@cemps.ac.cn
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研究方向

 水稻抗病的遗传与表观遗传

杨东雷

个人简介

杨东雷，中国科学院分子植物科学卓越创新中心研究员，博士生导师。长期致力于水稻抗病遗传与表观遗传的分子机制研究，在水稻与病原菌互作、抗病信号与产量性状互作、转基因的沉默机制、表观遗传因子在产量与抗病中的双重调控作用等方面取得了研究进展。先后获得江苏省杰出青年基金、国家级青年人才、“卫志明青年创新奖”、“全球杰出人才”等资助与荣誉，指导的博士生获得江苏省优秀博士论文。

教育与工作经历：
1999.09-2003.06：山东大学，生命科学学院，学士
2003.08-2009.11：中国科学院，植物生理与生态研究所，博士
2009.11-2010.12: 美国康乃尔大学，农学院,博士后
2011.01-2011.12: 美国普渡大学，农学院,博士后
2012.01-2014.12 中国科学院，上海生命科学研究院，副研究员
2015.01-2024.12 南京农业大学,农学院, 教授，博士生导师
2025.01－至今 中国科学院分子植物科学卓越创新中心，研究员，博士生导师

研究工作

粮食作物的高产稳产对保障我国粮食安全至关重要，病害是威胁粮食稳产的一个主要因素。克隆抗病基因并利用于遗传育种，培育出抗性品种是控制病害最经济安全的措施。但抗病基因的导入常常影响产量性状，如何协同改良抗病与产量性状是培育高产稳产作物新品种亟待解决的重要科学问题。本研究组长期从事水稻抗病遗传育种研究，利用遗传学、表观遗传学、分子生物学、生物信息学、生物化学等多种技术手段，筛选抗病新种质、克隆水稻抗病新基因、构建抗病的分子网络、解析抗性与产量性状互作的遗传与表观遗传机制，最终为水稻高产稳产新品种培育提供新材料、新基因、新理论与新技术。

研究组目前研究的几个方面：
(一) 克隆针对水稻主要病害的抗病新基因，解析其抗病分子机制；
(二) 解析抗病基因拮抗产量性状的分子网络，开发高产高抗育种新方法；
(三) 筛选利用防止转基因沉默的新种质，解析调控产量与抗病的表观因子。

 

     

    1. Xu D(#), Zeng L(#), Wang L, Yang D-L(*) Rice requires a chromatin remodeler for Polymerase IV-small interfering RNA production and genomic immunity. Plant Physiology. 2024, 194(4): 2149-2164

    2. Yang D-L(#)(*), Huang K, Deng D, Zeng Y, Wang Z(*), Zhang Y(*). DNA-dependent RNA polymerases in plants.The Plant Cell. 2023, 35(10): 3641-3661

    3. Wang L(#), Xu D, Zeng L, Yang D-L(*). The rise and fall of billionaire siRNAs during reproductive development in rice. Plants. 2022,11(15): 1957

    4. Wang L(#), Zheng K, Zeng L, Xu D, Zhu T, Yin Y, Zhan H, Wu Y, Yang D-L(*). Reinforcement of CHH methylation through RNA-directed DNA methylation ensures sexual reproduction in rice. Plant Physiology. 2022, Feb 4; 188(2):1189-1209

    5. Zheng K(#), Wang L(#), Zeng L(#), Xu D, Guo Z, Gao X, Yang D-L(*). The effect of RNA polymerase V on 24-nt siRNA accumulation depends on DNA methylation contexts and histone modifications in rice. PNAS. 2021, Jul 27;118(30):e2100709118.

    6. Deng Y(#), Ning Y(#), Yang D-L(#), Zhai K, Wang GL(*),He Z(*) Molecular Basis of Disease Resistance and Perspectives on Breeding Strategies for Resistance Improvement in Crops. Molecular Plant. 2020, Oct 5;13(10):1402-1419.

    7. 殷雨萌，曾龙军，王莉莉，郑克志，徐大超，杨东雷.水稻中的“伥鬼”：不同表观遗传学状态的同一转基因之间的相互作用。植物生理学报，2020, 56 (9): 1784–1794

    8. 杨东雷. 人们对水杨酸受体的认知再次深入。 植物生理学报，2020, 56 (11): 2329–2331

    9. Liu M(#), Shi Z(#), Zhang X, Wang M, Zhang L, Zheng K, Liu J, Hu X, Di C, Qian Q, He Z, Yang D-L(*). Inducible overexpression of Ideal Plant Architecture1 improves both yield and disease resistance in rice. Nature Plants. 2019, Apr; 5(4):389-400. ESI高被引论文

    10. Yang D-L(#)(*), Zhang G, Wang L, Li J, Xu D, Di C, Tang K, Yang L, Zeng L, Miki D, Duan CG, Zhang H, Zhu JK(*). Four putative SWI2/SNF2 chromatin remodelers have dual roles in regulating DNA methylation in Arabidopsis. Cell Discovery. 2018, Oct 16;4:55. doi: 10.1038/s41421-018-0056-8. 

    11. Li Y(#), Guo J, Yang Z, Yang D-L(*). Plasma Membrane-Localized Calcium Pumps and Copines Coordinately Regulate Pollen Germination and Fertility in Arabidopsis.International Journal ofMolecular Science. 2018, 19(6). pii: E1774. doi: 10.3390/ijms19061774.

    12. Yang D-L(#)(*), Shi Z(#), Bao Y(#), Yan J(#), Yang Z, Yu H, Li Y, Gou M, Wang S, Zou B, Xu D, Ma Z, Kim J, Hua J(*). Calcium pumps and interacting BON1 protein modulate calcium signature, stomatal closure, and plant immunity.Plant Physiology. 2017, 175(1): 424-437.

    13. Li X(#), Yang D-L(#), Sun L(#), Li Q, Mao B, He Z(*).The Systemic Acquired Resistance Regulator OsNPR1 Attenuates Growth by Repressing Auxin Signaling through Promoting IAA-Amido Synthase Expression. Plant Physiology. 2016, 172(1):546-558.

    14. Yang D-L(#),Zhang G(#), Tang K, Li J, Yang L, Huang H, Zhang H, Zhu JK(*). Dicer-independent RNA-directed DNA methylation in Arabidopsis. Cell Research. 2016, 26(1): 66-82.

    15. Zou B(#), Yang D-L(#), Shi Z(#), Dong H, Hua J(*). Monoubiquitination of Histone 2B at the disease resistance gene locus regulates its expression and impacts immune responses in Arabidopsis. Plant Physiology. 2014, 165(1):309-318.

    16. Sun L(#), Yang D-L(#),Kong Y, Chen Y, Li XZ, Zeng LJ, Li Q, Wang ET, He ZH(*). Sugar homeostasis mediated by cell wall invertase GRAIN INCOMPLETE FILLING 1 (GIF1) plays a role in pre-existing and induced defence in rice. Molecular Plant Pathology. 2014, 15(2):161-173.

    17. Yang D-L(#), Yang Y, He Z(*). Roles of plant hormones and their interplay in rice immunity. Molecular Plant 2013, 6(3):675-685. ESI高被引论文

    18. Yang D-L(#), Dong WX(#), Zhang YY, He ZH(*). Gibberellins modulate abiotic stress tolerance in plants. Scientia Sinica. 2013, 43(12): 1119-1126

    19. Yang D-L(#), Yao J(#), Mei CS(#),Tong XH, Zeng LJ, Li Q, Xiao LT, Sun TP, Li J, Deng XW, Lee CM, Thomashow MF, Yang Y(*), He Z(*), He SY(*). Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade. PNAS 2012, 109(19):E1192-1200. ESI高被引论文，F1000两次推荐

    20. Yang D-L(#), Li Q, Deng YW, Lou YG, Wang MY, Zhou GX, Zhang YY, He ZH(*). Altered disease development in the eui mutants and Eui overexpressors indicates that gibberellins negatively regulate rice basal disease resistance. Molecular Plant. 2008, 1:528-537.

    21. Dong K(#), Wu F(#), Cheng S(#), Li S, Zhang F, Xing X, Jin X, Luo S, Feng M, Miao R, Chang Y, Zhang S, You X, Wang P, Zhang X, Lei C, Ren Y, Zhu S, Guo X, Wu C, Yang D-L, Lin Q(*), Cheng Z(*), Wan J(*).  OsPRMT6a-mediated arginine methylation of OsJAZ1 regulates jasmonate signaling and spikelet development in rice. Molecular Plant. 2024,17(6):900-919. 

    22. Yan W(#), Zhu Y, Liu W, Zou C, Jia B, Chen Z-Q, Han Y, Wu J, Yang D-L, Zhang Z, Xie L, Chen B, Li R, Ding S-W, Wu Q, Guo Z(*). Discovery of aphid-transmitted Rice tiller inhibition virus from native plants through metagenomic sequencing. PLoS Pathogen2023, 19 (3)：e1011238

    23. Ai G(#), Yang D-L, Dou D(*). The warfare for plant highway: vascular plant–microbe interaction pinpoints lignin. Stress Biology. 2022. 2:24

    24. Fang Q(#), Zhang J, Yang D-L, Huang CF(*). The SUMO E3 ligase SIZ1 partially regulates STOP1 SUMOylation and stability in Arabidopsis thaliana. Plant Signal Behavior. 2021, 16:1899487

    25. Wan K(#), Lu K, Gao M, Zhao T, He Y, Yang D-L, Tao X, Xiong G, Guan X(*). Functional analysis of the cotton CLE polypeptide signaling gene family in plant growth and development. Scientific Reports. 2021, Mar 3;11(1):5060.

    26. Li J(#), Yang D-L, Huang H, Zhang G, He L, Pang J, Lozano-Durán R, Lang Z, Zhu JK(*). Epigenetic memory marks determine epiallele stability at loci targeted by de novo DNA methylation.Nature Plants. 2020, Jun;6(6):661-674. 

    27. Zhong Y(#), Wang W, Huang X, Liu M, Hebelstrup KH, Yang D-L, Cai J, Wang X, Zhou Q, Cao W, Dai T, Jiang D(*).Nitrogen topdressing timing modifies the gluten quality and grain hardness related protein levels as revealed by iTRAQ. Food Chem. 2019, Mar 30;277:135-144. 

    28. Zhang Q(#), Liang Z, Cui X, Ji C, Li Y, Zhang P, Liu J, Riaz A, Yao P, Liu M, Wang Y, Lu T, Yu H, Yang D-L, Zheng H, Gu X(*).N6-Methyladenine DNA Methylation in Japonica and Indica Rice Genomes and Its Association with Gene Expression, Plant Development and Stress Responses.Mol Plant. 2018, Dec 3;11(12):1492-1508.

    29. Zhong Y(#), Xu D, Hebelstrup KH, Yang D-L, Cai J, Wang X, Zhou Q, Cao W, Dai T, Jiang D(*). Nitrogen topdressing timing modifies free amino acids profiles and storage protein gene expression in wheat grain. BMC Plant Biol. 2018, Dec 13;18(1):353.

    30. Zhao K(#), Xiao J, Liu Y, Chen S, Yuan C, Cao A, You FM, Yang D-L, An S, Wang H, Wang X(*). Rht23 (5Dq') likely encodes a Q homeologue with pleiotropic effects on plant height and spike compactness. Theor Appl Genet. 2018, 131(9):1825-1834.

    31. Niu D(#), Zhang X, Song X, Wang Z, Li Y, Qiao L, Wang Z, Liu J, Deng Y, He Z, Yang D-L, Liu R, Wang Y, Zhao H(*). Deep sequencing uncovers rice long siRNAs and its involvement in immunity against Rhizoctonia solani. Phytopathology. 2018, 108(1):60-69.

    32. Wang L(#), Yuan J, Ma Y, Jiao W, Ye W, Yang D-L, Yi C, Chen ZJ(*). Rice Interploidy Crosses Disrupt Epigenetic Regulation, Gene Expression, and Seed Development. Molecular Plant. 2018, 11: 300-314.

    33. Zou B(#), Sun Q, Zhang W, Ding Y, Yang D-L, Shi Z, Hua J(*).The Arabidopsis Chromatin-Remodeling Factor CHR5 Regulates Plant Immune Responses and Nucleosome Occupancy. Plant Cell Physiology. 2017, 58(12):2202-2216.

    34. Yuan J(#), Chen S(#), Jiao W(#), Wang L, Wang L, Ye W, Lu J, Hong D, You S, Cheng Z, Yang D-L, Chen ZJ(*). Both maternally and paternally imprinted genes regulate seed development in rice. New Phytologist. 2017, 216(2):373-387. 

    35. You Q(#), Zhai K(#), Yang D-L, Yang W, Wu J, Liu J, Pan W, Wang J, Zhu X, Jian Y, Liu J, Zhang Y, Deng Y, Li Q, Lou Y, Xie Q, He Z(*).An E3 Ubiquitin Ligase-BAG Protein Module Controls Plant Innate Immunity and Broad-Spectrum Disease Resistance. Cell Host Microbe. 2016, 20(6):758-769.

    36. Zhang Q(#), Li Y, Xu T, Srivastava AK, Wang D, Zeng L, Yang L, He L, Zhang H, Zheng Z, Yang D-L, Zhao C, Dong J, Gong Z, Liu R, Zhu JK(*).The chromatin remodeler DDM1 promotes hybrid vigor by regulating salicylic acid metabolism. Cell Discovery. 2016, 2:16027.

    37. Wan Q(#), Guan X(#), Yang N, Wu H, Pan M, Liu B, Fang L, Yang S, Hu Y, Ye W, Zhang H, Ma P, Chen J, Wang Q, Mei G, Cai C, Yang D-L, Wang J, Guo W, Zhang W, Chen X(*), Zhang T(*).Small interfering RNAs from bidirectional transcripts of GhMML3_A12 regulate cotton fiber development. New Phytologist. 2016, 210(4):1298-1310.

    38. Xu J(#), Zhang L, Yang D-L, Li Q, He Z(*). Thymidine kinases share a conserved function for nucleotide salvage and play an essential role in Arabidopsis thaliana growth and development. New Phytologist. 2015, 208(4): 1089-1103.

    39. Feng Z(#), Mao Y, Xu N, Zhang B, Wei P, Yang D-L, Wang Z, Zhang Z, Zheng R, Yang L, Zeng L, Liu X, Zhu JK(*).Multigeneration analysis reveals the inheritance, specificity, and patterns of CRISPR/Cas-induced gene modifications in Arabidopsis. PNAS.2014, 111(12):4632-4637.

    40. Feng Z(#), Zhang B(#), Ding W, Liu X, Yang D-L, Wei P, Cao F, Zhu S, Zhang F, Mao Y, Zhu JK(*).Efficient genome editing in plants using a CRISPR/Cas system. Cell Research. 2013, 23(10):1229-1232. 

    41. Yan W(#), Ye S(#),, Jin Q, Zeng L, Peng Y, Yan D, Yang W, Yang D-L, He Z(*), Dong Y(*), Zhang X(*).Characterization and mapping of a novel mutant sms1 (senescence and male sterility 1) in rice. J Genet Genomics.2010, 37(1):47-55.

    42. Yuan Y(#), Zhong S, Li Q, Zhu Z, Lou Y, Wang L, Wang J, Wang M, Li Q, Yang D-L, He Z(*).Functional analysis of rice NPR1-like genes reveals that OsNPR1/NH1 is the rice orthologue conferring disease resistance with enhanced herbivore susceptibility. Plant Biotechnology Journal. 2007, 5(2):313-324.