首页　　 人才队伍
个人信息

博士生导师、中国科学院院士
研究员

1999年获得“国家杰出青年基金”


Email: xychen@cemps.ac.cn
个人网页: http://sippe.ac.cn/xy

研究方向

植物次生代谢和棉花生物学研究

陈晓亚

个人简介

1978年2月-1982年2月，南京大学生物系，获学士学位
1982年9月-1985年12月，英国Reading 大学，获植物学博士学位
1985年10月-1991年10月，南京大学生物系任教，讲师，副教授
1991年10月-1992年9月，德国Tuebingen大学植物学系进行访问研究
1992年9月-1994年10月，美国Purdue大学药物化学系做博士后研究
1994年10月至今，中国科学院上海植物生理生态研究所/分子植物卓越中心，研究员，博士生导师。
1999年获国家杰出青年基金资助，2005年当选中国科学院院士，2008年当选发展中国家科学院院士。

研究工作

从事植物次生代谢和棉花生物学研究，主要研究工作包括：
（1）植物次生代谢物的生物合成途径和调控机理，活性小分子化合物对植物环境适应和抗病虫反应的影响。
（2）棉花纤维品质和株型等性状形成的关键基因克隆与新材料创制，植物抗虫基因工程。

主要成果

植物次生代谢物在植物与环境、尤其是抗病抗虫过程中发挥重要作用，许多成分具有重要的药用或其它应用价值。研究组对植物倍半萜、尤其是棉酚和青蒿素生物的合成途径及调控开展了系统深入的研究，克隆鉴定了棉酚合成途径一系列酶和调控因子基因，解析了植物激素和microRNA调控倍半萜生物合成的分子机制。通过研究棉铃虫与植物的相互作用，发展了植物介导的RNA干扰抗虫技术，率先研发新一代植物抗虫技术。研究棉纤维发育及调控机理，分离鉴定了关键调控因子和细胞壁蛋白基因，阐述了植物激素GA在纤维发育过程中调控下游转录因子的机制；发现miRNA靶基因调控表皮毛和棉纤维发育，结果对棉纤维品质改良具有重要意义。

在国内外发表论文150余篇，包括Nature Biotechnology, Nature Communications, Plant Cell等国际重要刊物，申请或授权专利20多项。曾获何梁何利科学技术进步奖，全国优秀博士学位论文指导教师奖，国际棉花基因组指导委员会（ICGI）杰出贡献奖，上海科普教育创新奖科普杰出人物奖，上海市自然科学奖一等奖等。目前承担国家基金委基础科学中心、基金委重大、国家科技重大、国家重点研发、中科院等科研项目。

    1. Xu JJ, Lei Y, Zhang XF, Li JX, Lin Q, Wu XD, Jiang YG, Zhang W, Qian R, Xiong SY, Tan K, Jia Y, Zhou Q, Jiang Y, Fan H, Huang YB, Wang LJ, Liu JY, Kong Y, Zhao Q, Yang L, Liu J, Hu YH, Zhan S, Gao C*, Chen XY*. (2025). Design of CoQ10 crops based on evolutionary history. Cell. https://doi.org/10.1016/j.cell.2025.01.0232.

    2. Lin JL, Fang X, Li JX, Chen ZW, Wu WK, Guo XX, Liu NJ, Huang JF, Chen FY, Wang LJ, Xu B, Martin C, Chen XY*, Huang JQ*. (2023). Dirigent gene editing of gossypol enantiomers for toxicity-depleted cotton seeds. Nature Plants, 9, 605–615.

    3. Li CY, Yang L, Liu Y, Xu ZG, Gao J, Huang YB, Xu JJ, Fan H, Kong Y, Wei YK, Hu WL, Wang LJ, Zhao Q, Hu YH, Zhang YJ, Martin C, Chen XY*. (2022). The Sage Genome Provides Insight into the Evolutionary Dynamics of Diterpene Biosynthesis Gene Cluster in Plants. Cell reports. 40,111236.

    4. Xu JJ, Zhang XF, Jiang Y, Fan H, Li JX, Li CY, Zhao Q, Yang L, Hu YH, Martin C, Chen XY*. (2021). A unique flavoenzyme operates in ubiquinone biosynthesis in photosynthesis-related eukaryotes. Science Advances. 7:eabl3594.

    5. Liu NJ, Wang N, Bao JJ, Zhu HX, Wang LJ, Chen XY*. (2020). Lipidomic analysis reveals the importance of GIPCs in Arabidopsis leaf extracellular vesicles. Molecular Plant. 13(10):1523-1532.

    6. Cao JF, Zhao B, Huang CC, Chen ZW, Zhao T, Liu HR, Hu GJ, Shangguan XX, Shan CM, Wang LJ, Zhang TZ, Wendel JF, Guan XY*, Chen XY*. (2020). GhTCP4 promotes the transition from cell elongation to wall thickening in cotton fiber, Molecular Plant. 13(7):1063-1077.

    7. Huang JQ, Fang X, Tian X, Chen P, Lin JL, Guo XX, Li JX, Fan Z, Song WM, Chen FY, Ahati R, Wang LJ, Zhao Q, Martin C, Chen XY*. (2020). Aromatization of natural products by a specialized detoxification enzyme. Nature Chemical Biology. 16:250-256.

    8. Tian X, Ruan JX, Huang JQ, Yang CQ, Fang X, Chen ZW, Hong H, Wang LJ, Mao YB, Lu S, Zhang TZ*, Chen XY*. (2018). Characterization of gossypol biosynthetic pathway. Proc Natl Acad Sci U S A. 115: E5410-E5418.

    9. Zhao B, Cao JF, Hu GJ, Chen ZW, Wang LY, Shangguan XX, Wang LJ, Mao YB, Zhang TZ, Wendel JF*, Chen XY*. (2018）. Core cis-element variation confers subgenome-biased expression of a transcription factor that functions in cotton fiber elongation. New Phytologist, 218(3):1061-1075.

    10. Mao YB, Liu YQ, Chen DY, Chen FY, Fang X, Hong GJ, Wang LJ, Wang JW, Chen XY*. (2017) Jasmonate response decay and defense metabolite accumulation contributes to age-regulated dynamics of plant insect resistance. Nature Communications, 8:13925.

    11. Chao LM, Liu YQ, Chen DY, Xue XY, Mao YB, and Chen XY*. (2017) Arabidopsis transcription factors SPL1 and SPL12 confer plant thermotolerance at reproductive stage. Molecular Plant, 10: 735–748.

    12. Fang X, Li JX, Huang JQ, Xiao YL, Zhang P, Chen XY* .(2017) Systematic identification of functional residues of Artemisia annua amorpha-4,11-diene synthase. Biochem Journal, 474: 2191-2202.

    13. Wu XM, Yang CQ, Mao YB, Wang LJ, Shangguan XX, Chen XY*. (2016) Targeting insect mitochondrial complex I for plant protection. Plant Biotechnology Journal, 14: 1925-1935.

    14. Ma D, Hu Y, Yang C, Liu B, Fang L, Wan Q, Liang W, Mei G, Wang L, Wang H, Ding L, Dong C, Pan M, Chen J, Wang S, Chen S, Cai C, Zhu X, Guan X, Zhou B, Zhu S, Wang J, Guo W, Chen X*, Zhang T*. (2016) Genetic basis for glandular trichome formation in cotton. Nature Communications, 7:10456.

    15.Yu ZX, Wang LJ, Zhao B, Shan CM, Zhang YH, Chen DF, Chen XY*. (2015) Progressive regulation of sesquiterpene biosynthesis in Arabidopsis and Patchouli (Pogostemon cablin) by the miR156-targeted SPL transcription factors. Molecular Plant, 8:98-110.

    16. Zhang TZ, et al. (2015) Sequencing of allotetraploid cotton (Gossypium hirsutum L. acc. TM-1) provides a resource for fiber improvement. Nature Biotechnology 33,531–537.

    17. Shan CM, Shangguan XX, Zhao B, Zhang XF, Chao LM, Yang CQ, Wang LJ, Zhu HY, Zeng YD, Guo WZ, Zhou BL, Hu GJ, Guan XY, Chen JZ, Wendel JF, Zhang TZ*, Chen XY*. (2014) Control of cotton fibre elongation by a homeodomain transcription factor GhHOX3. Nature Communications, 5: 5519.

    18. Xue XY, Zhao B, Chao LM, Chen DY, Cui WR, Mao YB, Wang LJ, Chen XY*. (2014) Interaction between two timing microRNAs controls trichome distribution in Arabidopsis. PLoS Genetics, 10(4): e1004266.

    19. Hong GJ, Xue XY, Mao YB, Wang LJ, Chen XY*. (2012) Arabidopsis MYC2 interacts with DELLA proteins in regulating sesquiterpene synthase gene expression. Plant Cell, 24: 2635-2648.

    20. Xu B, Gou JY, Li FG, Shangguan XX, Zhao B, Yang CQ, Wang LJ, Yuan S, Liu CJ, Chen XY*. (2012) A cotton BURP domain protein interacts with α-expansin and their co-expression promotes plant growth and fruit production. Molecular Plant, 6(3): 945-958.

    21. Yu ZX, Li JX, Yang CQ, Hu WL, Wang LJ, Chen XY*. (2012) The jasmonate-responsive AP2/ERF transcription factors AaERF1 and AaERF2 positively regulate artemisinin biosynthesis in Artemisia annua L. Molecular Plant, 5: 353-365.

    22. Yu N, Cai WJ, Wang S, Shan CM, Wang LJ, Chen XY*. (2010) Temporal control of trichome distribution by miR156-targeted SPL genes in Arabidopsis thaliana. Plant Cell, 22: 2322–2335.

    23. Mao YB, Cai WJ, Wang JW, Hong GJ, Tao XY, Wang LJ, Huang YP, Chen XY*. (2007) Silencing a cotton bollworm P450 gene by plant-mediated RNAi impairs larval tolerance to gossypol. Nature Biotechnology, 25: 1307-1313.

    24. Wang JW, Wang LJ, Mao YB, Cai WJ, Xue HW, Chen XY*. (2005) Control of root cap formation by microRNA-targeted auxin response factors in Arabidopsis. Plant Cell, 17(8): 2204-2216.

    25. Wang GD, Li QJ, Luo B, Chen XY*. (2004) Ex planta phytoremediation of trichlorophenol and phenolic allelochemicals via an engineered secretory laccase. Nature Biotechnology, 22(7): 893-897.

    26. Wang S, Wang JW, Yu N, Li CH, Luo B, Gou JY, Wang LJ, Chen XY*. (2004) Control of plant trichome development by a cotton fiber MYB gene. Plant Cell, 16(9): 2323-2334.